The Role of Hypoxia-Associated Long Non-Coding RNAs in Breast Cancer

被引：14

作者：

Maldonado, Vilma ^{[1
]}

Melendez-Zajgla, Jorge ^{[2
]}

机构：

[1] Inst Nacl Med Genom, Canc Funct Genom Lab, Perifer 4809, Mexico City 14610, DF, Mexico

[2] Inst Nacl Med Genom, Epigenet Lab, Perifer 4809, Mexico City 14610, DF, Mexico

来源：

CELLS | 2022年 / 11卷 / 10期

关键词：

long non-coding RNAs; hypoxia; breast cancer; lncRNAs; CHROMATIN INTERACTIONS; BINDING SITES; TUMOR HYPOXIA; LNCRNA; HIF-1-ALPHA; PROMOTES; MALAT1; CELLS; MODEL; OVEREXPRESSION;

D O I：

10.3390/cells11101679

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Breast cancer is the leading cause of cancer-related deaths in women worldwide. In the United States, even with earlier diagnosis and treatment improvements, the decline in mortality has stagnated in recent years. More research is needed to provide better diagnostic, prognostic, and therapeutic tools for these patients. Long non-coding RNAs are newly described molecules that have extensive roles in breast cancer. Emerging reports have shown that there is a strong link between these RNAs and the hypoxic response of breast cancer cells, which may be an important factor for enhanced tumoral progression. In this review, we summarize the role of hypoxia-associated lncRNAs in the classic cancer hallmarks, describing their effects on the upstream and downstream hypoxia signaling pathway and the use of them as diagnostic and prognostic tools.

引用

页数：14

共 102 条

[41] The Eph/Ephrin family in cancer metastasis: communication at the service of invasion [J].

Kandouz, Mustapha .

CANCER AND METASTASIS REVIEWS, 2012, 31 (1-2) :353-373

[42] Tumor Microenvironment in Breast Cancer-Updates on Therapeutic Implications and Pathologic Assessment [J].

Li, Joshua J. ;

Tsang, Julia Y. ;

Tse, Gary M. .

CANCERS, 2021, 13 (16)

[43] Hypoxia-induced lncRNA RBM5-AS1 promotes tumorigenesis via activating Wnt/β-catenin signaling in breast cancer [J].

Li, Xinping ;

Yang, Jingyan ;

Ni, Ruiqi ;

Chen, Jintian ;

Zhou, Yanhao ;

Song, Hao ;

Jin, Liang ;

Pan, Yi .

CELL DEATH & DISEASE, 2022, 13 (02)

[44] RETRACTED: LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis (Retracted article. See vol. 21, 2022) [J].

Liang, Yiran ;

Song, Xiaojin ;

Li, Yaming ;

Chen, Bing ;

Zhao, Wenjing ;

Wang, Lijuan ;

Zhang, Hanwen ;

Liu, Ying ;

Han, Dianwen ;

Zhang, Ning ;

Ma, Tingting ;

Wang, Yajie ;

Ye, Fangzhou ;

Luo, Dan ;

Li, Xiaoyan ;

Yang, Qifeng .

MOLECULAR CANCER, 2020, 19 (01)

[45] The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer [J].

Lin, Aifu ;

Li, Chunlai ;

Xing, Zhen ;

Hu, Qingsong ;

Liang, Ke ;

Han, Leng ;

Wang, Cheng ;

Hawke, David H. ;

Wang, Shouyu ;

Zhang, Yanyan ;

Wei, Yongkun ;

Ma, Guolin ;

Park, Peter K. ;

Zhou, Jianwei ;

Zhou, Yan ;

Hu, Zhibin ;

Zhou, Yubin ;

Marks, Jeffery R. ;

Liang, Han ;

Hung, Mien-Chie ;

Lin, Chunru ;

Yang, Liuqing .

NATURE CELL BIOLOGY, 2016, 18 (02) :213-+

[46] Understanding the Deadly Silence of Posterior Fossa A Ependymoma [J].

Lin, Grant L. ;

Monje, Michelle .

MOLECULAR CELL, 2020, 78 (06) :999-1001

[47]

Lin Hsin-Chen, 2018, Oncotarget, V9, P10470, DOI 10.18632/oncotarget.23732

[48] Junk DNA and the long non-coding RNA twist in cancer genetics [J].

Ling, H. ;

Vincent, K. ;

Pichler, M. ;

Fodde, R. ;

Berindan-Neagoe, I. ;

Slack, F. J. ;

Calin, G. A. .

ONCOGENE, 2015, 34 (39) :5003-5011

[49] The roles of long noncoding RNAs in breast cancer metastasis [J].

Liu, Lingxia ;

Zhang, Yu ;

Lu, Jun .

CELL DEATH & DISEASE, 2020, 11 (09)

[50] A three-long noncoding RNA signature as a diagnostic biomarker for differentiating between triple-negative and non-triple-negative breast cancers [J].

Liu, Man ;

Xing, Lu-Qi ;

Liu, Yi-Jing .

MEDICINE, 2017, 96 (09)

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