The Role of Hypoxia-Associated Long Non-Coding RNAs in Breast Cancer

被引：14
作者：
Maldonado, Vilma [1 ]
Melendez-Zajgla, Jorge [2 ]
机构：
[1] Inst Nacl Med Genom, Canc Funct Genom Lab, Perifer 4809, Mexico City 14610, DF, Mexico
[2] Inst Nacl Med Genom, Epigenet Lab, Perifer 4809, Mexico City 14610, DF, Mexico
来源：
CELLS | 2022年 / 11卷 / 10期
关键词：
long non-coding RNAs; hypoxia; breast cancer; lncRNAs; CHROMATIN INTERACTIONS; BINDING SITES; TUMOR HYPOXIA; LNCRNA; HIF-1-ALPHA; PROMOTES; MALAT1; CELLS; MODEL; OVEREXPRESSION;
D O I：
10.3390/cells11101679
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Breast cancer is the leading cause of cancer-related deaths in women worldwide. In the United States, even with earlier diagnosis and treatment improvements, the decline in mortality has stagnated in recent years. More research is needed to provide better diagnostic, prognostic, and therapeutic tools for these patients. Long non-coding RNAs are newly described molecules that have extensive roles in breast cancer. Emerging reports have shown that there is a strong link between these RNAs and the hypoxic response of breast cancer cells, which may be an important factor for enhanced tumoral progression. In this review, we summarize the role of hypoxia-associated lncRNAs in the classic cancer hallmarks, describing their effects on the upstream and downstream hypoxia signaling pathway and the use of them as diagnostic and prognostic tools.
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页数：14
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