GLP-1 mimetics and cognition

被引：69

作者：

Yaribeygi, Habib ^{[1
]}

Rashidy-Pour, Ali ^{[1
]}

Atkin, Stephen L. ^{[2
]}

Jamialahmadi, Tannaz ^{[3
,4
]}

Sahebkar, Amirhossein ^{[5
,6
,7
,8
]}

机构：

[1] Semnan Univ Med Sci, Res Ctr Physiol, Semnan, Iran

[2] Weill Cornell Med Qatar, Doha, Qatar

[3] Islamic Azad Univ, Dept Food Sci & Technol, Quchan Branch, Quchan, Iran

[4] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran

[5] Mashhad Univ Med Sci, Biotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran

[6] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran

[7] FDA, Halal Res Ctr IRI, Tehran, Iran

[8] Polish Mothers Mem Hosp Res Inst PMMHRI, Lodz, Poland

来源：

LIFE SCIENCES | 2021年 / 264卷

关键词：

Glucagon-like peptide-1; Incretins; Diabetes mellitus; Cognition; Memory; Alzheimer's disease; GLUCAGON-LIKE PEPTIDE-1; HIPPOCAMPAL SYNAPTIC PLASTICITY; OXIDATIVE STRESS; RECEPTOR AGONIST; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; AMYLOID-BETA; MOUSE MODEL; GLUCOSE-HOMEOSTASIS; SIGNALING PATHWAYS;

D O I：

10.1016/j.lfs.2020.118645

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of antidiabetic drugs that improve the glycaemia via several molecular pathways. Recent evidence suggest that they also have additional effects modulating pathophysiologic pathways included in cognitive disorders. Since some forms of cognitive dysfunction such as Alzheimer's disease are more common among diabetic patients than in the normal population, antidiabetic drugs that have neuroprotective effects affording protection for cognitive disorders would be of benefit. Therefore, we reviewed the pharmacologic effects of GLP-1 analogues and found that they may have the additional benefit of improving cognitive performance via at least eight molecular mechanisms.

引用

页数：7

共 133 条

[1] Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease [J].