Bone morphogenetic protein-4

被引：30
|
作者：
Leong, LM
Brickell, PM
机构：
[1] INST CHILD HLTH,LEUKAEMIA RES FUND CTR CHILDHOOD LEUKAEMIA & MOL,LONDON WC1N 1EH,ENGLAND
[2] INST CHILD HLTH,MOL HAEMATOL UNIT,LONDON WC1N 1EH,ENGLAND
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1996年 / 28卷 / 12期
关键词：
D O I：
10.1016/S1357-2725(96)00075-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bone morphogenetic protein-4 (BMP-4) is one of nine structurally related BMPs belonging to the transforming growth factor-beta (TGF-beta) superfamily of secreted proteins. Mature BMP-4 is a dimer that binds to a multimeric transmembrane receptor with serine/threonine kinase activity. Although discovered because it stimulates bone formation in adult mammals, BMP-4 has important roles as a signalling molecule in embryonic tissues, including the developing central and peripheral nervous system, musculature and skeleton. It participates in an ancient signalling pathway also found in insects and worms. Nevertheless, the main practical application of BMPs is for stimulating repair of bone, and their use in humans is currently being assessed. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：1293 / 1296
页数：4
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