Multicomponent Synthesis of the Medicinally Important Pyrrolo[2,3-d]Pyrimidine Scaffold (Minireview)

被引：14

作者：

Dasari, R. ^{[1
]}

Kornienko, A. ^{[1
]}

机构：

[1] Texas State Univ, Dept Chem & Biochem, San Marcos, TX 78666 USA

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2014年 / 50卷 / 02期

关键词：

7-deazapurines; drug discovery; heterocycle; multicomponent reactions; privileged scaffold; ANTIVIRAL ACTIVITY; ANALOGS; DERIVATIVES; INHIBITORS; KINASE; PYRROLOPYRIMIDINE; PYRROLE; ALKALOIDS; DISCOVERY; ANTITUMOR;

D O I：

10.1007/s10593-014-1456-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Multicomponent reactions are emerging as a powerful tool in the synthesis of heterocyclic privileged medicinal scaffolds. This highlight describes a recently developed approach to the construction of the medicinally important pyrrolo[2,3-d]pyrimidine scaffold using a one-pot synthesis from commercially available starting materials via novel multicomponent reactions.

引用

页码：139 / 144

页数：6

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