Minocycline attenuates noise-induced hearing loss in rats

被引：9

作者：

Zhang, Jing ^{[1
]}

Song, Yong-Li ^{[1
]}

Tian, Ke-Yong ^{[1
]}

Qiu, Jian-Hua ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Dept Otolaryngol Head & Neck Surg, 169 Changle Rd, Xian 710038, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2017年 / 639卷

关键词：

Noise-induced hearing loss; Minocycline; Auditory brainstem response; INDUCED OTOTOXICITY; OXIDATIVE STRESS; FREE-RADICALS; D-METHIONINE; EXPOSURE; NEUROPROTECTION; ANTIOXIDANTS; INHIBITION; ACTIVATION; COCHLEA;

D O I：

10.1016/j.neulet.2016.12.039

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Noise-induced hearing loss (NIHL) is a serious health concern and prevention of hair cell death or therapeutic intervention at the early stage of NIHL is critical to preserve hearing. Minocycline is a semi-synthetic derivative of tetracycline and has been shown to have otoprotective effects in ototoxic drug-induced hearing impairment, however, whether minocycline can protect against NIHL has not been investigated. The present study demonstrated elevated ABR (auditory brainstem response) thresholds and outer hair cell loss following traumatic noise exposure, which was mitigated by intraperitoneal administration of minocycline (45 mg/kg/d) for 5 consecutive days. In conclusion, the present study demonstrated that minocycline, a clinically approved drug with a good safety profile, can attenuate NIHL in rats and may potentially be used for treatment of hearing loss in clinic. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：31 / 35

页数：5

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