X-chromosome inactivation and escape

被引：97

作者：

Disteche, Christine M. ^{[1
,2
]}

Berletch, Joel B. ^{[1
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Med, Seattle, WA 98195 USA

来源：

JOURNAL OF GENETICS | 2015年 / 94卷 / 04期

基金：

美国国家卫生研究院;

关键词：

X chromosome; X inactivation; escape from X inactivation; XIST RNA; DOSAGE COMPENSATION; DNA METHYLATION; INTELLECTUAL DISABILITY; REGULATORY ELEMENTS; RESOLUTION REVEALS; Y-CHROMOSOMES; GENE-ACTION; MOUSE; CHROMATIN;

D O I：

10.1007/s12041-015-0574-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

X-chromosome inactivation, which was discovered by Mary Lyon in 1961 results in random silencing of one X chromosome in female mammals. This review is dedicated to Mary Lyon, who passed away last year. She predicted many of the features of X inactivation, for e.g., the existence of an X inactivation center, the role of L1 elements in spreading of silencing and the existence of genes that escape X inactivation. Starting from her published work here we summarize advances in the field.

引用

页码：591 / 599

页数：9

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