X-chromosome inactivation and escape

被引：95
|
作者：
Disteche, Christine M. [1 ,2 ]
Berletch, Joel B. [1 ]
机构：
[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA
[2] Univ Washington, Dept Med, Seattle, WA 98195 USA
来源：
JOURNAL OF GENETICS | 2015年 / 94卷 / 04期
基金：
美国国家卫生研究院;
关键词：
X chromosome; X inactivation; escape from X inactivation; XIST RNA; DOSAGE COMPENSATION; DNA METHYLATION; INTELLECTUAL DISABILITY; REGULATORY ELEMENTS; RESOLUTION REVEALS; Y-CHROMOSOMES; GENE-ACTION; MOUSE; CHROMATIN;
D O I：
10.1007/s12041-015-0574-1
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
X-chromosome inactivation, which was discovered by Mary Lyon in 1961 results in random silencing of one X chromosome in female mammals. This review is dedicated to Mary Lyon, who passed away last year. She predicted many of the features of X inactivation, for e.g., the existence of an X inactivation center, the role of L1 elements in spreading of silencing and the existence of genes that escape X inactivation. Starting from her published work here we summarize advances in the field.
引用
收藏
页码：591 / 599
页数：9
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