The effect of treatment delay on quality of life and overall survival in head and neck cancer patients

被引：7
作者：
Schoonbeek, Rosanne C. [1 ]
de Vries, Julius [1 ]
Bras, Linda [1 ]
Sidorenkov, Grigory [2 ]
Plaat, Boudewijn E. C. [1 ]
Witjes, Max J. H. [3 ]
van der Laan, Bernard F. A. M. [1 ,4 ]
van den Hoek, Johanna G. M. [5 ]
van Dijk, Boukje A. C. [2 ,6 ]
Langendijk, Johannes A. [5 ]
Halmos, Gyorgy B. [1 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, Hanzepl 1, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Dept Oral & Maxillofacial Surg, Groningen, Netherlands
[4] Haaglanden Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, The Hague, Netherlands
[5] Univ Groningen, Univ Med Ctr Groningen, Dept Radiat Oncol, Groningen, Netherlands
[6] Netherlands Comprehens Canc Org IKNL, Dept Res, Utrecht, Netherlands
来源：
EUROPEAN JOURNAL OF CANCER CARE | 2022年 / 31卷 / 04期
关键词：
head and neck neoplasms; overall survival; quality of life; time-to-treatment; treatment delay; TREATMENT INITIATION; TREATMENT INTERVAL; INCREASING TIME; DIAGNOSIS; IMPACT; RADIOTHERAPY; ASSOCIATION; OUTCOMES; QLQ-C30;
D O I：
10.1111/ecc.13589
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective Head and neck squamous cell carcinomas (HNSCC) are rapidly developing tumours, and substantial delay in treatment initiation is associated with decreased overall survival. The effect of delay on health-related quality of life (HRQOL) is unknown. The aim of this study was to assess the impact of delay on QOL and overall survival. Methods Patients with mucosal HNSCC were prospectively included. HRQOL and 2-year overall survival were analysed using linear mixed-model analyses and cox regression, respectively. Delay was defined as care pathway interval (CPI) of >= 30 days between first consultation and treatment initiation. Results Median CPI was 39 days for the 173 patients included. A trend towards higher HRQOL-scores (indicating better HRQOL) during 2-year follow-up for patients with delay in treatment initiation was visible in the adjusted models (HRQOL summary score-beta: 2.62, 95% CI: 0.57-4.67, p = 0.012). Factors associated with decreased overall survival were moderate comorbidities (HR: 5.10, 95% CI: 1.65-15.76, p = 0.005) and stage-IV tumours (HR: 12.37, 95% CI: 2.81-54.39, p = 0.001). Delay was not associated with worse overall survival. Conclusion Timely treatment initiation is challenging, especially for patients with advanced tumours and initial radiotherapy treatment. Encountering delay in treatment initiation did not result in clinically relevant differences in HRQOL-scores or decreased overall survival during 2-year follow-up.
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页数：10
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