Bifidobacterium adolescentis regulates catalase activity and host metabolism and improves healthspan and lifespan in multiple species

被引：28
作者：
Chen, Shujie [1 ,2 ]
Chen, Luyi [1 ,2 ]
Qi, Yadong [1 ,2 ]
Xu, Jilei [1 ,2 ]
Ge, Qiwei [2 ,3 ]
Fan, Yuedan [4 ,5 ,6 ]
Chen, Du [4 ,5 ,6 ]
Zhang, Yawen [1 ,2 ]
Wang, Lan [1 ,2 ]
Hou, Tongyao [1 ,2 ]
Yang, Xiaohang [7 ,8 ]
Xi, Yongmei [7 ,8 ]
Si, Jianmin [1 ,2 ]
Kang, Lijun [4 ,5 ,6 ]
Wang, Liangjing [2 ,3 ]
机构：
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Gastroenterol, Sch Med, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Prevent & Treatment Res Ctr Senescent Dis, Sch Med, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Gastroenterol, Hangzhou, Zhejiang, Peoples R China
[4] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Neurobiol, Hangzhou, Zhejiang, Peoples R China
[5] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Neurosurg, Hangzhou, Zhejiang, Peoples R China
[6] Zhejiang Univ, NHC & CAMS Key Lab Med Neurobiol, MOE Frontier Sci Ctr Brain Res & Brain Machine In, Sch Brain Sci & Brain Med, Hangzhou, Zhejiang, Peoples R China
[7] Zhejiang Univ, Inst Genet, Hangzhou, Zhejiang, Peoples R China
[8] Zhejiang Univ, Dept Genet, Div Human Reprod & Dev Genet, Womens Hosp, Hangzhou, Zhejiang, Peoples R China
来源：
NATURE AGING | 2021年 / 1卷 / 11期
基金：
国家重点研发计划;
关键词：
D O I：
10.1038/s43587-021-00129-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
To identify candidate bacteria associated with aging, we performed fecal microbiota sequencing in young, middle-aged and older adults, and found lower Bifidobacterium adolescentis abundance in older individuals aged >= 60years. Dietary supplementation of B. adolescentis improved osteoporosis and neurodegeneration in a mouse model of premature aging (Terc(-/-)) and increased healthspan and lifespan in Drosophila melanogaster and Caenorhabditis elegans. B. adolescentis supplementation increased the activity of the catalase (CAT) enzyme in skeletal muscle and brain tissue from Terc(-/-) mice, and suppressed cellular senescence in mouse embryonic fibroblasts. Transgenic deletion of catalase (ctl-2) in C. elegans abolished the effects of B. adolescentis on the lifespan and healthspan. B. adolescentis feeding also led to changes in oxidative stress-associated metabolites in Terc(-/-) mouse feces. These results suggest a role for B. adolescentis in improving the healthspan and lifespan through the regulation of CAT activity and host metabolism.
引用
收藏
页码：991 / +
页数：24
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