Solid phase synthesis of heterocyclic compounds from linear peptides: Cyclic ureas and thioureas

被引：66

作者：

Nefzi, A ^{[1
]}

Ostresh, JM ^{[1
]}

Meyer, JP ^{[1
]}

Houghten, RA ^{[1
]}

机构：

[1] TORREY PINES INST MOL STUDIES, SAN DIEGO, CA 92121 USA

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(96)02516-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The solid phase synthesis of cyclic ureas and thioureas is described. The reduction of acylated dipeptides followed by treatment with carbonyldiimidazole or thiocarbonyldiimidazole affords the corresponding cyclic urea or thiourea in good yield and high purity. This is an example of a broader approach to the solid phase synthesis of individual heterocyclic compounds and combinatorial libraries using peptides as starting materials. (C) 1997, Elsevier Science Ltd.

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页码：931 / 934

页数：4

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