Translation initiation and its deregulation during tumorigenesis

被引：60

作者：

Watkins, SJ ^{[1
]}

Norbury, CJ ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Canc Res UK Mol Oncol Lab, Oxford OX3 9DS, England

来源：

BRITISH JOURNAL OF CANCER | 2002年 / 86卷 / 07期

关键词：

translation; translation initiation factors (eIFs); growth control; internal ribosome entry sites (IRES);

D O I：

10.1038/sj/bjc/6600222

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Regulation of protein synthesis at the level of translation initiation is fundamentally important for the control of cell proliferation under normal physiological conditions. Conversely, misregulation of protein synthesis is emerging as a major contributory factor in cancer development, Most bulk protein synthesis is initiated via recognition of the mRNA 5' cap and subsequent recognition of the initiator AUG codon by a directional scanning mechanism. However, several key regulators of tumour development are translated by a cap-independent pathway. Here we review eukaryotic translation initiation, its regulation and the ways in which this regulation can break down during tumorigenesis. (C) 2002 Cancer Research UK.

引用

页码：1023 / 1027

页数：5

共 37 条

[1]

Berkel HJ, 2001, CANCER EPIDEM BIOMAR, V10, P663

[2] Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma [J].