Senescent cells: a therapeutic target for cardiovascular disease

被引：142

作者：

Childs, Bennett G. ^{[1
]}

Li, Hu ^{[2
]}

van Deursen, Jan M. ^{[1
,3
]}

机构：

[1] Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN USA

[2] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA

[3] Mayo Clin, Dept Pediat & Adolescent Med, Rochester, MN USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2018年 / 128卷 / 04期

关键词：

SMOOTH-MUSCLE-CELLS; DNA-DAMAGE-RESPONSE; PRESERVED EJECTION FRACTION; ONCOGENE-INDUCED SENESCENCE; RENIN-ANGIOTENSIN SYSTEM; CORONARY-ARTERY SPASM; CARDIAC STEM-CELL; HEART-FAILURE; NITRIC-OXIDE; PREMATURE SENESCENCE;

D O I：

10.1172/JCI95146

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cellular senescence, a major tumor-suppressive cell fate, has emerged from humble beginnings as an in vitro phenomenon into recognition as a fundamental mechanism of aging. In the process, senescent cells have attracted attention as a therapeutic target for age-related diseases, including cardiovascular disease (CVD), the leading cause of morbidity and mortality in the elderly. Given the aging global population and the inadequacy of current medical management, attenuating the health care burden of CVD would be transformative to clinical practice. Here, we review the evidence that cellular senescence drives CVD in a bimodal fashion by both priming the aged cardiovascular system for disease and driving established disease forward. Hence, the growing field of senotherapy (neutralizing senescent cells for therapeutic benefit) is poised to contribute to both prevention and treatment of CVD.

引用

页码：1217 / 1228

页数：12

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