Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion

被引：10

作者：

Arioka, Yuko ^{[1
,2
,3
]}

Kushima, Itaru ^{[1
,3
]}

Kubo, Hisako ^{[1
]}

Mori, Daisuke ^{[1
,4
]}

Ozaki, Norio ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Psychiat, Nagoya, Aichi, Japan

[2] Nagoya Univ Hosp, Ctr Adv Med & Clin Res, Nagoya, Aichi 4668560, Japan

[3] Nagoya Univ, Inst Adv Res, Nagoya, Aichi, Japan

[4] Nagoya Univ, Brain & Mind Res Ctr, Nagoya, Aichi, Japan

来源：

STEM CELL RESEARCH | 2018年 / 30卷

关键词：

D O I：

10.1016/j.scr.2018.05.013

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Astrotactin-2, encoded by ASTN2, is implicated in neuronal migration. Although genetic studies of schizophrenia (SCZ) patients have suggested that exonic deletions of ASTN2 are associated with neurodevelopmental and psychiatric disorders, their biological significance remains unclear. Herein, we generated human induced pluripotent stem cells (iPSCs) from a SCZ patient with an exonic deletion of ASTN2. The generated iPSCs carried ASTN2 deletion and showed typical iPSC morphology, pluripotency marker expression, normal chromosomal aneuploidy, and the capacity to differentiate into three germ layers. This iPSC line may be suitable for evaluating Astrotactin-2 function relevant for SCZ onset in the human brain.

引用

页码：81 / 84

页数：4

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