A metal ion regulated artificial metalloenzyme

被引：15

作者：

Bersellini, Manuela ^{[1
]}

Roelfes, Gerard ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, Nijenborgh 4, NL-9747 AG Groningen, Netherlands

来源：

DALTON TRANSACTIONS | 2017年 / 46卷 / 13期

基金：

欧洲研究理事会;

关键词：

BIS(OXAZOLINYL)PYRIDINE-SCANDIUM(III) TRIFLATE COMPLEXES; FRIEDEL-CRAFTS ALKYLATIONS; UNNATURAL AMINO-ACIDS; ALLOSTERIC REGULATION; BINDING; 1,10-PHENANTHROLINE; 2,2-BIPYRIDINE; CATALYSIS; DESIGN; LMRR;

D O I：

10.1039/c7dt00533d

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Regulation of enzyme activity is essential in living cells. The rapidly increasing number of designer enzymes with new-to-nature activities makes it necessary to develop novel strategies for controlling their catalytic activity. Here we present the development of a metal ion regulated artificial metalloenzyme created by combining two anchoring strategies, covalent and supramolecular, for introducing a regulatory and a catalytic site, respectively. This artificial metalloenzyme is activated in the presence of Fe2+ ions, but only marginally in the presence of Zn2+.

引用

页码：4325 / 4330

页数：6

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