Tools for the Microbiome: Nano and Beyond

被引：115

作者：

Biteen, Julie S. ^{[1
]}

Blainey, Paul C. ^{[2
,3
]}

Cardon, Zoe G. ^{[4
]}

Chun, Miyoung ^{[5
]}

Church, George M. ^{[6
,8
,9
]}

Dorrestein, Pieter C. ^{[10
]}

Fraser, Scott E. ^{[15
]}

Gilbert, Jack A. ^{[16
,17
,18
]}

Jansson, Janet K. ^{[19
]}

Knight, Rob ^{[11
,12
]}

Miller, Jeff F. ^{[20
,21
]}

Ozcan, Aydogan ^{[20
,22
,23
]}

Prather, Kimberly A. ^{[13
,14
]}

Quake, Stephen R. ^{[26
,27
]}

Ruby, Edward G. ^{[28
]}

Silver, Pamela A. ^{[7
,8
,9
]}

Taha, Sharif ^{[5
]}

van den Engh, Ger ^{[29
,30
]}

Weiss, Paul S. ^{[20
,24
,25
]}

Wong, Gerard C. L. ^{[20
,23
,24
]}

Wright, Aaron T. ^{[19
]}

Young, Thomas D. ^{[20
,24
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[2] MIT, Dept Biol Engn, Cambridge, MA 02138 USA

[3] Broad Inst MIT & Harvard, Cambridge, MA 02138 USA

[4] Marine Biol Lab, Ctr Ecosyst, Woods Hole, MA 02543 USA

[5] Kavli Fdn, Oxnard, CA 93030 USA

[6] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[7] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

[8] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[9] Harvard Univ, Biophys Program, Boston, MA 02115 USA

[10] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci Biochem Pharmac, La Jolla, CA 92093 USA

[11] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

[12] Univ Calif San Diego, Dept Comp Sci & Engn, La Jolla, CA 92093 USA

[13] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[14] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA

[15] Univ So Calif, Translat Imaging Ctr, Mol & Computat Biol, Los Angeles, CA 90089 USA

[16] Argonne Natl Lab, Inst Genom & Syst Biol, 9700 S Cass Ave, Argonne, IL 60439 USA

[17] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA

[18] Univ Chicago, Dept Surg, Chicago, IL 60637 USA

[19] Pacific NW Natl Lab, Earth & Biol Sci Div, Richland, WA 99352 USA

[20] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA

[21] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

[22] Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA

[23] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[24] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[25] Univ Calif Los Angeles, Dept Mat Sci & Engn, Los Angeles, CA 90095 USA

[26] Stanford Univ, Dept Appl Phys & Bioengn, Stanford, CA 94305 USA

[27] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

[28] Univ Hawaii Manoa, Kewalo Marine Lab, Honolulu, HI 96813 USA

[29] Ctr Marine Cytometry, Concrete, Washington, DC USA

[30] Univ Concepcion, Inst Milenio Oceanog, Concepcion, Chile

来源：

ACS NANO | 2016年 / 10卷 / 01期

基金：

美国国家科学基金会;

关键词：

AIRBORNE BACTERIAL COMMUNITIES; SELF-ASSEMBLED MONOLAYERS; SINGLE-CELL ANALYSIS; HUMAN GUT SYMBIONT; ICE NUCLEATION; SEQUENCING TECHNOLOGIES; MOLECULAR ANALYSIS; GLOBAL ATMOSPHERE; RESOLUTION LIMIT; BODY HABITATS;

D O I：

10.1021/acsnano.5b07826

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The microbiome presents great opportunities for understanding and improving the world around us and elucidating the interactions that compose it. The microbiome also poses tremendous challenges for mapping and manipulating the entangled networks of interactions among myriad diverse organisms. Here, we describe the opportunities, technical needs, and potential approaches to address these challenges, based on recent and upcoming advances in measurement and control at the nanoscale and beyond. These technical needs will provide the basis for advancing the largely descriptive studies of the microbiome to the theoretical and mechanistic understandings that will underpin the discipline of microbiome engineering. We anticipate that the new tools and methods developed will also be more broadly useful in environmental monitoring, medicine, forensics, and other areas.

引用

页码：6 / 37

页数：32

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