Impact of the Platelet-to-Lymphocyte Ratio as a Biomarker for Esophageal Squamous Cell Carcinoma

被引：8
|
作者：
Kato, Takashi [1 ]
Oshikiri, Taro [1 ]
Goto, Hironobu [1 ]
Sawada, Ryuichiro [1 ]
Harada, Hitoshi [1 ]
Urakawa, Naoki [1 ]
Hasegawa, Hiroshi [1 ]
Kanaji, Shingo [1 ]
Yamashita, Kimihiro [1 ]
Matsuda, Takeru [2 ]
Kakeji, Yoshihiro [1 ]
机构：
[1] Kobe Univ, Grad Sch Med, Dept Surg, Div Gastrointestinal Surg, Kobe, Hyogo, Japan
[2] Kobe Univ, Grad Sch Med, Dept Surg, Div Minimally Invas Surg, Kobe, Hyogo, Japan
来源：
ANTICANCER RESEARCH | 2022年 / 42卷 / 05期
关键词：
Biomarker; esophageal squamous cell carcinoma; platelet-to-lymphocyte ratio; RECURRENT LARYNGEAL NERVE; CHARACTERISTIC ROC CURVE; LAPAROSCOPIC SURGERY; CANCER; LYMPHADENECTOMY; INFLAMMATION; LEUKOCYTE; SURVIVAL; OUTCOMES;
D O I：
10.21873/anticanres.15757
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: Esophageal squamous cell carcinoma (ESCC) is a deadly malignant disease. This study examined whether the platelet-to-lymphocyte ratio (PLR) can be used as a biomarker to evaluate prognosis in patients with advanced ESCC following neoadjuvant chemotherapy (NAC) and undergoing minimally invasive esophagectomy (MIE). Patients and Methods: We examined 174 patients between January 2010 and December 2015 at the Kobe University. Of these, 121 were treated with NAC. The PLR cutoff was determined through receiver-operating characteristic curve analysis. Univariate and multivariate analyses were conducted to identify prognostic factors for overall survival (OS). Results: The PLR cutoff for OS in 121 patients was 169.6. Patients with PLR 169.6 (61.1%, p=0.001). Multivariate analysis revealed that a PLR of 169.6 was an independent factor for poor prognosis. Conclusion: PLR is an independent prognostic factor for patients with ESCC after NAC and MIE.
引用
收藏
页码：2775 / 2782
页数：8
相关论文
共 50 条
  • [1] Platelet-to-lymphocyte ratio is an independent prognosticator in patients with esophageal squamous cell carcinoma receiving esophagectomy
    Chen, Li-Chun
    Li, Shau-Hsuan
    Lo, Chien-Ming
    Chen, Yen-Hao
    Huang, Shun-Chen
    Wang, Yu-Ming
    Chou, Shang-Yu
    Lu, Hung-I
    JOURNAL OF THORACIC DISEASE, 2019, 11 (11) : 4583 - 4590
  • [2] Effect of dynamic platelet-to-lymphocyte ratio on the prognosis of patients with esophageal squamous cell carcinoma receiving chemoradiotherapy
    He, Dan
    Du, Shulan
    He, Songyuan
    Song, Hao
    Pu, Bo
    Zhang, Guojun
    Yang, Chuan
    MEDICINE, 2023, 102 (49) : E36554
  • [3] Combined score based on plasma fibrinogen and platelet-lymphocyte ratio as a prognostic biomarker in esophageal squamous cell carcinoma
    Yang, Yuchong
    Tan, Hui
    Lu, Yao
    Mei, Jipeng
    Zhang, Mengqi
    Bai, Ming
    Wang, Xia
    Ge, Shaohua
    Ning, Tao
    Zhang, Le
    Ji, Zhi
    Duan, Jingjing
    Sun, Yansha
    Wang, Feixue
    Liu, Rui
    Li, Hongli
    Deng, Ting
    BMC CANCER, 2024, 24 (01)
  • [4] Pretreatment Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Prognostic Factors and Reference Markers of Treatment Options for Locally Advanced Squamous Cell Carcinoma Located in the Middle and Upper Esophagus
    Wang, Chen
    Tong, Jiaqi
    Tang, Mengqiu
    Lu, Yunyun
    Liang, Gaofeng
    Zhang, Zhanchun
    Chen, Tian
    CANCER MANAGEMENT AND RESEARCH, 2021, 13 : 1075 - 1085
  • [5] Lymphocyte-to-monocyte ratio in esophageal squamous cell carcinoma prognosis
    Hu, Gang
    Liu, Gang
    Ma, Jian-ying
    Hu, Ru-jin
    CLINICA CHIMICA ACTA, 2018, 486 : 44 - 48
  • [6] The prognostic role of pre-treatment neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in esophageal squamous cell carcinoma treated with concurrent chemoradiotherapy
    Man, Qirong
    Li, Peishun
    Fan, Jing
    Yang, Sen
    Xing, Chao
    Bai, Yunling
    Hu, Miaomiao
    Wang, Baohu
    Zhang, Kaixian
    BMC CANCER, 2024, 24 (01)
  • [7] Prognostic Value of Lymph Node Density Compared to Pre-operative Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients with Tongue Squamous Cell Carcinoma
    Khazravi, Mona
    Shirkhoda, Mohammad
    Saffar, Hana
    Jalaeefar, Amirmohsen
    JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, 2022, 21 (03): : 845 - 855
  • [8] Combined score based on plasma fibrinogen and platelet-lymphocyte ratio as a prognostic biomarker in esophageal squamous cell carcinoma
    Yuchong Yang
    Hui Tan
    Yao Lu
    Jipeng Mei
    Mengqi Zhang
    Ming Bai
    Xia Wang
    Shaohua Ge
    Tao Ning
    Le Zhang
    Zhi Ji
    Jingjing Duan
    Yansha Sun
    Feixue Wang
    Rui Liu
    Hongli Li
    Ting Deng
    BMC Cancer, 24
  • [9] Clinicopathological and prognostic significance of platelet-to-lymphocyte ratio in patients with hepatocellular carcinoma
    Song, Wei
    Wang, Kai
    Zhong, Fu-ping
    Fan, You-wen
    Peng, Lang
    Zou, Shu-bing
    ONCOTARGET, 2016, 7 (49) : 81830 - 81838
  • [10] The Prognostic Capacity of Systemic Inflammation Response Index, Neutrophil-to-Lymphocyte Ratio, Lymphocyte-to-Monocyte Ratio, and Platelet-to-Lymphocyte Ratio in Patients with Hypopharyngeal Squamous Cell Carcinoma
    Wang, Tian
    Lin, Hanqing
    Hsueh, Chiyao
    Lau, Hui-Ching
    Zhou, Jian
    Gong, Hongli
    Tao, Lei
    Zhou, Liang
    Wu, Chunping
    ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY, 2022, 84 (06): : 453 - 463
12345