Electrochemical Method to Characterize Multidrug Resistance

被引：1

作者：

Lu Shan ^{[1
]}

Ning Limin ^{[2
]}

Gao Tao ^{[2
]}

Wu Xiaolan ^{[2
]}

Yin Yongmei ^{[1
]}

Li Genxi ^{[2
,3
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Oncol, Nanjing 210029, Jiangsu, Peoples R China

[2] Nanjing Univ, Dept Biochem, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China

[3] Shanghai Univ, Sch Life Sci, Lab Biosensing Technol, Shanghai 200444, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2014年 / 30卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Multidrug resistance; Mitoxantrone; Drug efflux; Electrochemistry; P-GLYCOPROTEIN; LEUKEMIA-CELLS; EXPRESSION; MRP1; 6-MERCAPTOPURINE; MITOXANTRONE; TRANSPORTER; DOXORUBICIN; CISPLATIN; PROTEINS;

D O I：

10.1007/s40242-014-4153-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multidrug resistance(MDR) is a main factor to make the failure of chemotherapy. It is closely related to the over-expression of P-glycoprotein(P-gp), multidrug resistance protein(MRP) and breast cancer resistance protein(BCRP). Herein we reported a novel method to characterize MDR, taking advantage of the electrochemical property of chemotherapeutic drugs. Meanwhile, the definition of accumulation phase and retention phase has been improved. Furthermore, with specific modulators introduced to inhibit the relevant efflux pumps, the exact protein that mainly works in the cells employed in this study can be identified.

引用

页码：437 / 440

页数：4

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