Chromatin Repressive Complexes in Stem Cells, Development, and Cancer

被引：269

作者：

Laugesen, Anne ^{[1
,2
,3
]}

Helin, Kristian ^{[1
,2
,3
]}

机构：

[1] Univ Copenhagen, BRIC, DK-2200 Copenhagen, Denmark

[2] Univ Copenhagen, Ctr Epigenet, DK-2200 Copenhagen, Denmark

[3] Univ Copenhagen, Danish Stem Cell Ctr DanStem, DK-2200 Copenhagen, Denmark

来源：

CELL STEM CELL | 2014年 / 14卷 / 06期

基金：

新加坡国家研究基金会; 欧洲研究理事会;

关键词：

POLYCOMB GROUP PROTEINS; HISTONE METHYLTRANSFERASE EZH2; HEMATOPOIETIC STEM; SELF-RENEWAL; SOMATIC MUTATIONS; GENE EZH2; TRANSCRIPTIONAL NETWORKS; TARGETED DISRUPTION; TUMOR-SUPPRESSOR; SELECTIVE-INHIBITION;

D O I：

10.1016/j.stem.2014.05.006

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The chromatin environment is essential for the correct specification and preservation of cell identity through modulation and maintenance of transcription patterns. Many chromatin regulators are required for development, stem cell maintenance, and differentiation. Here, we review the roles of the polycomb repressive complexes, PRC1 and PRC2, and the HDAC1- and HDAC2-containing complexes, NuRD, Sin3, and CoREST, in stem cells, development, and cancer, as well as the ongoing efforts to develop therapies targeting these complexes in human cancer. Furthermore, we discuss the role of repressive complexes in modulating thresholds for gene activation and their importance for specification and maintenance of cell fate.

引用

页码：735 / 751

页数：17

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