Emerging clinical and therapeutic applications of Nigella sativa in gastroenterology

被引:17
作者
Kapoor, Shailendra
机构
关键词
Nigella sativa; Thymoquinone; Colon cancer; Glutathione-S transferase; Schistosomiasis; CANCER CELLS; TREATED RATS; COLON-CANCER; THYMOQUINONE; EXTRACTS; INJURY; AGENTS; LIVER; OIL;
D O I
10.3748/wjg.15.2170
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Nigella sativa decreases DNA damage and thereby prevents initiation of carcinogenesis in colonic tissue secondary to exposure to toxic agents such as azoxymethane. N. sativa is of immense therapeutic benefit in diabetic individuals and those with glucose intolerance as it accentuates glucose-induced secretion of insulin besides having a negative impact on glucose absorption from the intestinal mucosa. N. sativa administration protects hepatic tissue from deleterious effects of toxic metals such as lead, and attenuates hepatic lipid peroxidation following exposure to chemicals such as carbon tetrachloride. (C) 2009 The WIG Press and Baishideng. All rights reserved
引用
收藏
页码:2170 / 2171
页数:2
相关论文
共 15 条
[1]   Role of Nigella sativa and a Number of its Antioxidant Constituents towards Azoxymethane-induced Genotoxic Effects and Colon Cancer in Rats [J].
Al-Johar, Dalal ;
Shinwari, Neptune ;
Arif, Jamal ;
Al-Sanea, Nasser ;
Jabbar, Alaa Abdul ;
El-Sayed, Ra'afat ;
Mashhour, Abdullah ;
Billedo, Grisellhi ;
El-Doush, Inaam ;
Al-Saleh, Iman .
PHYTOTHERAPY RESEARCH, 2008, 22 (10) :1311-1323
[2]   Effect of black cumin (Nigella sativa) on heart rate, some hematological values, and pancreatic β-cell damage in cadmium-treated rats [J].
Demir, Halit ;
Kanter, Mehmet ;
Coskun, Omer ;
Uz, Yesim Hulya ;
Koc, Ahmet ;
Yildiz, Abdulmelik .
BIOLOGICAL TRACE ELEMENT RESEARCH, 2006, 110 (02) :151-162
[3]   The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as anti-schistosomiasis agents in mice [J].
El Shenawy, Nuhla S. ;
Soliman, Maha F. M. ;
Reyad, Shimaa I. .
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, 2008, 50 (01) :29-36
[4]  
Farrag Abdel-Razik H, 2007, Pak J Biol Sci, V10, P2809, DOI 10.3923/pjbs.2007.2809.2816
[5]  
Gali-Muhtasib H, 2004, INT J ONCOL, V25, P857
[6]  
Iddamaldeniya S S, 2006, J Carcinog, V5, P11, DOI 10.1186/1477-3163-5-11
[7]   Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats [J].
Kanter, Mehmet ;
Demir, Halit ;
Karakaya, Cengiz ;
Ozbek, Hanefi .
WORLD JOURNAL OF GASTROENTEROLOGY, 2005, 11 (42) :6662-6666
[8]   Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats [J].
Kanter, Mehmet ;
Coskun, Omer ;
Budancamanak, Mustafa .
WORLD JOURNAL OF GASTROENTEROLOGY, 2005, 11 (42) :6684-6688
[9]   Anti-tumor properties of blackseed (Nigella sativa L.) extracts [J].
Mbarek, L. Ait ;
Mouse, H. Ait ;
Elabbadi, N. ;
Bensalah, M. ;
Gamouh, A. ;
Aboufatima, R. ;
Benharref, A. ;
Chait, A. ;
Kamal, M. ;
Dalal, A. ;
Zyad, A. .
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2007, 40 (06) :839-847
[10]   Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats [J].
Meddah, Bouchra ;
Ducroc, Robert ;
Faouzi, Moulay El Abbes ;
Eto, Bruno ;
Mahraoui, Lahcen ;
Benhaddou-Andaloussi, Ali ;
Martineau, Louis Charles ;
Cherrah, Yahia ;
Haddad, Pierre Selim .
JOURNAL OF ETHNOPHARMACOLOGY, 2009, 121 (03) :419-424