Frit-free PDMS microfluidic device for chromatographic separation and on-chip detection

被引:23
作者
Kabiri, Shervin [1 ]
Kurkuri, Mahaveer D. [1 ,2 ]
Kumeria, Tushar [1 ]
Losic, Dusan [1 ]
机构
[1] Univ Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia
[2] Jain Univ, Ctr Nano & Mat Sci, Bangalore 562112, Karnataka, India
基金
澳大利亚研究理事会;
关键词
PHASE LIQUID-CHROMATOGRAPHY; STATIONARY PHASES; SILICA PARTICLES; ELECTROCHROMATOGRAPHY; MICROCHIPS; DIATOMS; COLUMN; NANOTECHNOLOGY; FABRICATION; SYSTEMS;
D O I
10.1039/c4ra01393j
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A simple frit-free PDMS (polydimethylsiloxane) microfluidic chromatographic device, packed with diatomaceous earth (DE) microparticles as a normal phase stationary material using iron oxide magnetic nanoparticles is described. The separation of two model dyes was successfully demonstrated by integrating on-chip fibre optic detection to create a lab on a chip type of device.
引用
收藏
页码:15276 / 15280
页数:5
相关论文
共 29 条
[1]  
Aw MS, 2011, NANOMEDICINE-UK, V6, P1159, DOI [10.2217/nnm.11.29, 10.2217/NNM.11.29]
[2]   Tuning drug loading and release properties of diatom silica microparticles by surface modifications [J].
Bariana, Manpreet ;
Aw, Moom Sinn ;
Kurkuri, Mahaveer ;
Losic, Dusan .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2013, 443 (1-2) :230-241
[3]   An integrated fritless column for on-chip capillary electrochromatography with conventional stationary phases [J].
Ceriotti, L ;
de Rooij, NF ;
Verpoorte, E .
ANALYTICAL CHEMISTRY, 2002, 74 (03) :639-647
[4]   Review on the chemical and thermal stability of stationary phases for reversed-phase liquid chromatography [J].
Claessens, HA ;
van Straten, MA .
JOURNAL OF CHROMATOGRAPHY A, 2004, 1060 (1-2) :23-41
[5]   Electroosmosis- and pressure-driven chromatography in chips using continuous beds [J].
Ericson, C ;
Holm, J ;
Ericson, T ;
Hjertén, S .
ANALYTICAL CHEMISTRY, 2000, 72 (01) :81-87
[6]   Electrochromatography in microchips packed with conventional reversed-phase silica particles [J].
Gaspar, Attila ;
Hernandez, Lilia ;
Stevens, Schetema ;
Gomez, Frank A. .
ELECTROPHORESIS, 2008, 29 (08) :1638-1642
[7]   Fabrication of fritless chromatographic microchips packed with conventional reversed-phase silica particles [J].
Gaspar, Attila ;
Piyasena, Menake E. ;
Gomez, Frank A. .
ANALYTICAL CHEMISTRY, 2007, 79 (20) :7906-7909
[8]   Integration of ground aerogel particles as chromatographic stationary phase into microchip [J].
Gaspar, Attila ;
Nagy, Andrea ;
Lazar, Istvan .
JOURNAL OF CHROMATOGRAPHY A, 2011, 1218 (07) :1011-1015
[9]   The Glass Menagerie: diatoms for novel applications in nanotechnology [J].
Gordon, Richard ;
Losic, Dusan ;
Tiffany, Mary Ann ;
Nagy, Stephen S. ;
Sterrenburg, Frithjof A. S. .
TRENDS IN BIOTECHNOLOGY, 2009, 27 (02) :116-127
[10]   Fabrication of nanocolumns for liquid chromatography [J].
He, B ;
Tait, N ;
Regnier, F .
ANALYTICAL CHEMISTRY, 1998, 70 (18) :3790-3797