Intensity-modulated radiation therapy for prostate cancer

被引：88

作者：

Zelefsky, MJ ^{[1
]}

Fuks, Z ^{[1
]}

Leibel, SA ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10021 USA

来源：

SEMINARS IN RADIATION ONCOLOGY | 2002年 / 12卷 / 03期

关键词：

D O I：

10.1053/srao.2002.00000

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Intensity-modulated radiation therapy (IMRT) represents a new paradigm in radiation treatment planning and delivery for treatment of prostate cancer with enormous potential. Preliminary data indicate that this highly conformal treatment technique can effectively reduce acute and late-occurring toxicities, improving the quality of life of the treated patient and serving as the optimal dose escalation tool. IMRT produces radiation distributions capable of delivering different dose prescriptions to multiple target sites, providing a new opportunity for differential dose painting to increase the dose selectively to specific, image-defined regions within the prostate. Clinical trials will be necessary to define more clearly the true extent of improved tumor control and reduction in normal tissue complications with IMRT in the treatment of prostate cancer. Copyright 2002, Elsevier Science (USA). All rights reserved.

引用

页码：229 / 237

页数：9

共 34 条

[11]

Kutcher, 1995, Semin Radiat Oncol, V5, P134, DOI 10.1016/S1053-4296(95)80006-9

[12] Beneficial effect of combination hormonal therapy administered prior and following external beam radiation therapy in localized prostate cancer [J].

Laverdiere, J ;

Gomez, JL ;

Cusan, L ;

Suburu, ER ;

Diamond, P ;

Lemay, M ;

Candas, B ;

Fortin, A ;

Labrie, F .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1997, 37 (02) :247-252

[13] PATTERNS OF CARE OUTCOME STUDIES - RESULTS OF THE NATIONAL PRACTICE IN ADENOCARCINOMA OF THE PROSTATE [J].

LEIBEL, SA ;

HANKS, GE ;

KRAMER, S .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1984, 10 (03) :401-409

[14] THE BIOLOGICAL BASIS FOR CONFORMAL 3-DIMENSIONAL RADIATION-THERAPY [J].

LEIBEL, SA ;

LING, CC ;

KUTCHER, GJ ;

MOHAN, R ;

CORDONCORDO, C ;

FUKS, Z .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1991, 21 (03) :805-811

[15]

LEIBEL SA, 2000, 3D CONFORMAL RAD THE

[16] Conformal radiation treatment of prostate cancer using inversely-planned intensity-modulated photon beams produced with dynamic multileaf collimation [J].

Ling, CC ;

Burman, C ;

Chui, CS ;

Kutcher, GJ ;

Leibel, SA ;

LoSasso, T ;

Mohan, R ;

Bortfeld, T ;

Reinstein, L ;

Spirou, S ;

Wang, XH ;

Wu, QW ;

Zelefsky, M ;

Fuks, Z .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1996, 35 (04) :721-730

[17] Importance of high radiation doses (72 Gy or greater) in the treatment of stage T1-T3 adenocarcinoma of the prostate [J].

Lyons, JA ;

Kupellan, PA ;

Mohan, DS ;

Reddy, CA ;

Klein, EA .

UROLOGY, 2000, 55 (01) :85-90

[18] Reduction of small and large bowel irradiation using an optimized intensity-modulated pelvic radiotherapy technique in patients with prostate cancer [J].

Nutting, CM ;

Convery, DJ ;

Cosgrove, VP ;

Rowbottom, C ;

Padhani, AR ;

Webb, S ;

Dearnaley, DP .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2000, 48 (03) :649-656

[19] Static field intensity modulation to treat a dominant intra-prostatic lesion to 90 Gy compared to seven field 3-dimensional radiotherapy [J].

Pickett, B ;

Vigneault, E ;

Kurhanewicz, J ;

Verhey, L ;

Roach, M .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1999, 44 (04) :921-929

[20] Preliminary results of a randomized radiotherapy dose-escalation study comparing 70 Gy with 78 Gy for prostate cancer [J].

Pollack, A ;

Zagars, GK ;

Smith, LG ;

Lee, JJ ;

von Eschenbach, AC ;

Antolak, JA ;

Starkschall, G ;

Rosen, I .

JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (23) :3904-3911

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