Local delivery of CAR T cells targeting fibroblast activation protein is safe in patients with pleural mesothelioma: first report of FAPME, a phase I clinical trial

被引：64

作者：

Hiltbrunner, S. ^{[1
,2
]}

Britschgi, C. ^{[1
,2
]}

Schuberth, P. ^{[1
,2
]}

Bankel, L. ^{[1
,2
]}

Nguyen-Kim, T. D. L. ^{[3
,8
]}

Gulati, P. ^{[4
]}

Weder, W. ^{[5
]}

Opitz, I. ^{[5
]}

Lauk, O. ^{[5
]}

Caviezel, C. ^{[5
]}

Bachmann, H. ^{[1
,2
]}

Tabor, A. ^{[6
]}

Schroder, P. ^{[6
]}

Knuth, A. ^{[1
,2
]}

Munz, C. ^{[4
]}

Stahel, R. ^{[1
,2
,8
]}

Boyman, O. ^{[7
,8
]}

Renner, C. ^{[9
,10
]}

Petrausch, U. ^{[8
]}

Curioni-Fontecedro, A. ^{[1
,2
,8
]}

机构：

[1] Univ Hosp Zurich, Dept Med Oncol & Hematol, Zurich, Switzerland

[2] Univ Zurich, Comprehens Canc Ctr Zurich, Zurich, Switzerland

[3] Univ Hosp Zurich, Inst Diagnost & Intervent Radiol, Zurich, Switzerland

[4] Univ Zurich, Inst Expt Immunol, Zurich, Switzerland

[5] Univ Hosp Zurich, Dept Thorac Surg, Zurich, Switzerland

[6] Biontech Innovat Mfg Serv, Idar Oberstein, Germany

[7] Univ Hosp Zurich, Dept Immunol, Zurich, Switzerland

[8] Univ Zurich, Fac Med, Zurich, Switzerland

[9] Univ Basel, Fac Med, Basel, Switzerland

[10] Onkozentrum Zurich, Swiss Tumor Immunol Inst, Zurich, Switzerland

来源：

ANNALS OF ONCOLOGY | 2021年 / 32卷 / 01期

关键词：

D O I：

10.1016/j.annonc.2020.10.474

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：120 / 121

页数：2

共 5 条

[1] Considerations for the Clinical Application of Chimeric Antigen Receptor T Cells: Observations from a Recombinant DNA Advisory Committee Symposium Held June 15, 2010 [J].

Ertl, Hildegund C. J. ;

Zaia, John ;

Rosenberg, Steven A. ;

June, Carl H. ;

Dotti, Gianpietro ;

Kahn, Jeffrey ;

Cooper, Laurence J. N. ;

Corrigan-Curay, Jacqueline ;

Strome, Scott E. .

CANCER RESEARCH, 2011, 71 (09) :3175-3181

[2] Aberrant Lck Signal via CD28 Costimulation Augments Antigen-Specific Functionality and Tumor Control by Redirected T Cells with PD-1 Blockade in Humanized Mice [J].

Gulati, Pratiksha ;

Ruhl, Julia ;

Kannan, Abhilash ;

Pircher, Magdalena ;

Schuberth, Petra ;

Nytko, Katarzyna J. ;

Pruschy, Martin ;

Sulser, Simon ;

Haefner, Mark ;

Jensen, Shawn ;

Soltermann, Alex ;

Jungraithmayr, Wolfgang ;

Eisenring, Maya ;

Winder, Thomas ;

Samaras, Panagiotis ;

Tabor, Annett ;

Stenger, Rene ;

Stupp, Roger ;

Weder, Walter ;

Renner, Christoph ;

Munz, Christian ;

Petrausch, Ulf .

CLINICAL CANCER RESEARCH, 2018, 24 (16) :3981-3993

[3] Re-directed T cells for the treatment of fibroblast activation protein (FAP)-positive malignant pleural mesothelioma (FAPME-1) [J].

Petrausch, Ulf ;

Schuberth, Petra C. ;

Hagedorn, Christian ;

Soltermann, Alex ;

Tomaszek, Sandra ;

Stahel, Rolf ;

Weder, Walter ;

Renner, Christoph .

BMC CANCER, 2012, 12

[4] Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma [J].

Schuster, Stephen J. ;

Bishop, Michael R. ;

Tam, Constantine S. ;

Waller, Edmund K. ;

Borchmann, Peter ;

McGuirk, Joseph P. ;

Jaeger, Ulrich ;

Jaglowski, Samantha ;

Andreadis, Charalambos ;

Westin, Jason R. ;

Fleury, Isabelle ;

Bachanova, Veronika ;

Foley, S. Ronan ;

Ho, P. Joy p ;

Mielke, Stephan ;

Magenau, John M. ;

Holte, Harald ;

Pantano, Serafino ;

Pacaud, Lida B. ;

Awasthi, Rakesh ;

Chu, Jufen ;

Anak, Ozlem ;

Salles, Gilles ;

Maziarz, Richard T. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (01) :45-56

[5] Neoadjuvant chemotherapy and extrapleural pneumonectomy of malignant pleural mesothelioma with or without hemithoracic radiotherapy (SAKK 17/04): a randomised, international, multicentre phase 2 trial [J].

Stahel, Rolf A. ;

Riesterer, Oliver ;

Xyrafas, Alexandros ;

Opitz, Isabelle ;

Beyeler, Michael ;

Ochsenbein, Adrian ;

Frueh, Martin ;

Cathomas, Richard ;

Nackaerts, Kristiaan ;

Peters, Solange ;

Mamot, Christoph ;

Zippelius, Alfred ;

Mordasini, Carlo ;

Caspar, Clemens B. ;

Eckhardt, Katrin ;

Schmid, Ralph A. ;

Aebersold, Daniel M. ;

Gautschi, Oliver ;

Nagel, Wolfgang ;

Toepfer, Michael ;

Krayenbuehl, Jerome ;

Ribi, Karin ;

Ciernik, Ilja F. ;

Weder, Walter .

LANCET ONCOLOGY, 2015, 16 (16) :1651-1658

← 1 →