Adaptive optics optical coherence tomography with dynamic retinal tracking

被引：45
作者：
Kocaoglu, Omer P. [1 ]
Ferguson, R. Daniel [2 ]
Jonnal, Ravi S. [1 ]
Liu, Zhuolin [1 ]
Wang, Qiang [1 ]
Hammer, Daniel X. [2 ]
Miller, Donald T. [1 ]
机构：
[1] Indiana Univ, Sch Optometry, Bloomington, IN 47405 USA
[2] Phys Sci Inc, Andover, MA 01810 USA
来源：
BIOMEDICAL OPTICS EXPRESS | 2014年 / 5卷 / 07期
关键词：
SCANNING LASER OPHTHALMOSCOPE; CHROMATIC ABERRATION CORRECTION; HIGH-SPEED; CONE PHOTORECEPTORS; DIMENSIONS; RESOLUTION; EYE; OCT; PHASE; SYSTEM;
D O I：
10.1364/BOE.5.002262
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Adaptive optics optical coherence tomography (AO-OCT) is a highly sensitive and noninvasive method for three dimensional imaging of the microscopic retina. Like all in vivo retinal imaging techniques, however, it suffers the effects of involuntary eye movements that occur even under normal fixation. In this study we investigated dynamic retinal tracking to measure and correct eye motion at KHz rates for AO-OCT imaging. A customized retina tracking module was integrated into the sample arm of the 2nd-generation Indiana AO-OCT system and images were acquired on three subjects. Analyses were developed based on temporal amplitude and spatial power spectra in conjunction with strip-wise registration to independently measure AO-OCT tracking performance. After optimization of the tracker parameters, the system was found to correct eye movements up to 100 Hz and reduce residual motion to 10 m root mean square. Between session precision was 33 m. Performance was limited by tracker-generated noise at high temporal frequencies. (C) 2014 Optical Society of America
引用
收藏
页码：2262 / 2284
页数：23
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