Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease

被引：7

作者：

Teng, Long ^{[1
]}

Hong, Fang ^{[1
]}

Zhang, Chenguang ^{[1
]}

He, Jiancheng ^{[1
]}

Wang, Haiying ^{[1
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 04期

基金：

中国国家自然科学基金;

关键词：

nerve regeneration; traditional Chinese medicine; Parkinson's disease; dyskinesia; excitatory amino acid; inhibitory amino acid; neurobehavior; Compound Formula Rehmannia; NSFC grant; neural regeneration; SUBSTANTIA-NIGRA; PATHOPHYSIOLOGY;

D O I：

10.4103/1673-5374.128246

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Compound Formula Rehmannia has been shown to be clinically effective in treating Parkinson's disease and levodopa-induced dyskinesia; however, the mechanisms remain unclear. In this study, we established a model of Parkinson's disease dyskinesia in rats, and treated these animals with Compound Formula Rehmannia. Compound Formula Rehmannia inhibited the increase in mRNA expression of N-methyl-D-aspartate receptor subunits 1 and 2 and excitatory amino acid neurotransmitter genes, and it inhibited the reduction in expression of gamma-aminobutyric acid receptor B1, an inhibitory amino acid neurotransmitter gene, in the corpus striatum. In addition, Compound Formula Rehmannia alleviated dyskinesia symptoms in the Parkinson's disease rats. These experimental findings indicate that Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease by modulating neurotransmitter signaling in the corpus striatum.

引用

页码：407 / 412

页数：6

共 30 条

[1]

Bao XM., 1991, STEREOTAXIC ATLAS RA

[2] Prospects of glutamate antagonists in the therapy of Parkinson's disease [J].

Blandini, F ;

Greenamyre, JT .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1998, 12 (01) :4-12

[3]

[曹丽双 Cao Lishuang], 2011, [时珍国医国药, Lishizhen Medicine and Materia Medica Research], V22, P3006

[4] PARTIAL LESION OF THE SUBSTANTIA-NIGRA - RELATION BETWEEN EXTENT OF LESION AND ROTATIONAL BEHAVIOR [J].

CARMAN, LS ;

GAGE, FH ;

SHULTS, CW .

BRAIN RESEARCH, 1991, 553 (02) :275-283

[5]

Ding HJ, 2010, RES AUTHENTICATION S

[6]

Ding HJ, 2010, HOHH 4 NAT C INT TRA

[7]

[丁宏娟 Ding Hongjuan], 2011, [西安交通大学学报. 医学版, Journal of Xi'an Jiaotong University. Medical Sciences], V32, P93

[8] Targeting Glutamate Receptors to Tackle the Pathogenesis, Clinical Symptoms and Levodopa-Induced Dyskinesia Associated with Parkinson's Disease [J].

Duty, Susan .

CNS DRUGS, 2012, 26 (12) :1017-1032

[9] Levodopa-induced dyskinesias [J].

Fabbrini, Giovanni ;

Brotchie, Jonathan M. ;

Grandas, Francisco ;

Nomoto, Masahiro ;

Goetz, Christopher G. .

MOVEMENT DISORDERS, 2007, 22 (10) :1379-1389

[10]

[葛晶 Ge Jing], 2012, [时珍国医国药, Lishizhen Medicine and Materia Medica Research], V23, P3070

← 1 2 3 →