Advances in Pediatric Intravenous Iron Therapy

被引：43
作者：
Mantadakis, Elpis [1 ,2 ]
机构：
[1] Democritus Univ Thrace, Fac Med, Dept Pediat, Pediat Hematol Oncol Unit, Alexandroupolis 68100, Thrace, Greece
[2] Univ Gen Dist Hosp Evros, Alexandroupolis, Thrace, Greece
来源：
PEDIATRIC BLOOD & CANCER | 2016年 / 63卷 / 01期
关键词：
children; ferric carboxymaltose; ferric gluconate; ferumoxytol; iron deficiency anemia; iron sucrose; INFLAMMATORY-BOWEL-DISEASE; FERRIC CARBOXYMALTOSE TREATMENT; RESTLESS LEGS SYNDROME; MOLECULAR-WEIGHT IRON; DEFICIENCY ANEMIA; CONTROLLED-TRIAL; CHILDREN; MANAGEMENT; EFFICACY; SAFETY;
D O I：
10.1002/pbc.25752
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Iron deficiency anemia (IDA) continues to be very common worldwide. Intravenous (IV) iron is an infrequently used therapeutic option in children with IDA despite numerous studies in adults and several small but notable pediatric studies showing efficacy and safety. Presently, the availability of newer IV iron products allows for replacement of the total iron deficit at a single setting. These products appear safer compared to the high molecular weight iron dextrans of the past. Herein, we review the medical literature and suggest that front line use of IV iron should be strongly considered in diseases associated with IDA in children. Pediatr Blood Cancer (c) 2015 Wiley Periodicals, Inc.
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页码：11 / 16
页数：6
相关论文
共 66 条
[1]   Treatment of iron deficiency anemia with intravenous iron preparations [J].
Akarsu, Saadet ;
Taskin, Erdal ;
Yilmaz, Erdal ;
Yilmaz, Huseyin ;
Kilic, Mehmet ;
Aygun, A. Denizmen .
ACTA HAEMATOLOGICA, 2006, 116 (01) :51-57
[2]   Responsiveness to Parenteral Iron Therapy in Children with Oral Iron-Refractory Iron-Deficiency Anemia [J].
Akin, Mehmet ;
Atay, Enver ;
Oztekin, Osman ;
Karadeniz, Cem ;
Karakus, Yasin Tugrul ;
Yilmaz, Bilal ;
Erdogan, Firat .
PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2014, 31 (01) :57-61
[3]   Intravenous iron: From anathema to standard of care [J].
Auerbach, Michael ;
Coyne, Dan ;
Ballard, Harold .
AMERICAN JOURNAL OF HEMATOLOGY, 2008, 83 (07) :580-588
[4]   Clinical Use of Intravenous Iron: Administration, Efficacy, and Safety [J].
Auerbach, Michael ;
Ballard, Harold .
HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2010, :338-347
[5]   Should Intravenous Iron be Upfront Therapy for Iron Deficiency Anemia? [J].
Auerbach, Michael .
PEDIATRIC BLOOD & CANCER, 2011, 56 (04) :511-512
[6]   The Safety of Intravenous Iron Preparations: Systematic Review and Meta-analysis [J].
Avni, Tomer ;
Bieber, Amir ;
Grossman, Alon ;
Green, Hefziba ;
Leibovici, Leonard ;
Gafter-Gvili, Anat .
MAYO CLINIC PROCEEDINGS, 2015, 90 (01) :12-23
[7]   Iron Status and Analysis of Efficacy and Safety of Ferric Carboxymaltose Treatment in Patients with Inflammatory Bowel Disease [J].
Beigel, Florian ;
Loehr, Beate ;
Laubender, Ruediger P. ;
Tillack, Cornelia ;
Schnitzler, Fabian ;
Breiteneicher, Simone ;
Weidinger, Maria ;
Goeke, Burkhard ;
Seiderer, Julia ;
Ochsenkuehn, Thomas ;
Brand, Stephan .
DIGESTION, 2012, 85 (01) :47-54
[8]   Hypersensitivity from Intravenous Iron Products [J].
Bircher, Andreas J. ;
Auerbach, Michael .
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2014, 34 (03) :707-+
[9]   Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia [J].
Bregman, David B. ;
Morris, David ;
Koch, Todd A. ;
He, Andy ;
Goodnough, Lawrence T. .
AMERICAN JOURNAL OF HEMATOLOGY, 2013, 88 (02) :97-101
[10]   Cost-Minimization Analysis Favours Intravenous Ferric Carboxymaltose over Ferric Sucrose for the Ambulatory Treatment of Severe Iron Deficiency [J].
Calvet, Xavier ;
Angel Ruiz, Miquel ;
Dosal, Angelina ;
Moreno, Laura ;
Lopez, Maria ;
Figuerola, Ariadna ;
Suarez, David ;
Miquel, Mireia ;
Villoria, Albert ;
Gene, Emili .
PLOS ONE, 2012, 7 (09)
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