Acute myeloid leukemia presenting with panhypopituitarism or diabetes insipidus: a case series with molecular genetic analysis and review of the literature

被引：12

作者：

Cull, Elizabeth H. ^{[1
,2
]}

Watts, Justin M. ^{[3
]}

Tallman, Martin S. ^{[3
]}

Kopp, Peter ^{[2
,4
]}

Frattini, Mark ^{[3
,5
]}

Rapaport, Franck ^{[3
]}

Rampal, Raajit ^{[3
]}

Levine, Ross ^{[3
]}

Altman, Jessica K. ^{[1
,2
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Div Hematol Oncol, Dept Med, Chicago, IL 60611 USA

[2] NW Mem Hosp, Chicago, IL 60611 USA

[3] Weill Cornell Med Coll, Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY USA

[4] Northwestern Univ, Feinberg Sch Med, Div Endocrinol Metab & Mol Med, Chicago, IL 60611 USA

[5] Columbia Univ, Dept Med, Med Ctr, New York, NY USA

来源：

LEUKEMIA & LYMPHOMA | 2014年 / 55卷 / 09期

关键词：

Acute myeloid leukemia; diabetes insipidus; panhypopituitarism; ACUTE MYELOBLASTIC-LEUKEMIA; MYELODYSPLASTIC SYNDROME; MONOSOMY-7; ABNORMALITIES; CHROMOSOME-3;

D O I：

10.3109/10428194.2013.869327

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Central diabetes insipidus (DI) is a rare finding in patients with acute myeloid leukemia (AML), usually occurring in patients with chromosome 3 or 7 abnormalities. We describe four patients with AML and concurrent DI and a fifth patient with AML and panhypopituitarism. Four of five patients had monosomy 7. Three patients had chromosome 3q21q26/EVI-1 gene rearrangements. The molecular genotype of patients with AML and DI is not known. Therefore, we performed gene sequencing of 30 genes commonly mutated in AML in three patients with available leukemia cell DNA. One patient had no identifiable mutations, and two had RUNX1 F158S mutations.

引用

页码：2125 / 2129

页数：5

共 14 条

[1] 3 NEW CASES OF CHROMOSOME-3 REARRANGEMENT IN BAND-Q21 AND BAND-Q26 WITH ABNORMAL THROMBOPOIESIS BRING FURTHER EVIDENCE TO THE EXISTENCE OF A 3Q21Q26-SYNDROME [J].

BELLOMO, MJ ;

PARLIER, V ;

MUHLEMATTER, D ;

GROB, JP ;

BERIS, P .

CANCER GENETICS AND CYTOGENETICS, 1992, 59 (02) :138-160

[2]

DELACHAPELLE A, 1987, EUR J HAEMATOL, V39, P404

[3] Acute myeloblastic leukemia associated with hyperleukocytosis and diabetes insipidus [J].

Dilek, I ;

Uysal, A ;

Demirer, T ;

Koc, H ;

Özcan, M ;

Keles, H ;

Numanoglu, N ;

Üstün, C ;

Çiftçi, E .

LEUKEMIA & LYMPHOMA, 1998, 30 (5-6) :657-660

[4] Acute myeloid leukaemia with trilineage myelodysplasia complicated by masked diabetes insipidus [J].

Endo, T ;

Tamai, Y ;

Takami, H ;

Matsuki, A ;

Munakata, A .

CLINICAL AND LABORATORY HAEMATOLOGY, 2000, 22 (04) :233-235

[5] Thrombotic disease in the myeloproliferative neoplasms [J].

Falanga, Anna ;

Marchetti, Marina .

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2012, :571-581

[6] Acute myeloid leukemia and diabetes insipidus with monosomy 7 [J].

Harb, Antoine ;

Tan, Wei ;

Wilding, Gregory E. ;

Battiwalla, Mincio ;

Sait, Shella N. J. ;

Wang, Eunice S. ;

Wetzler, Meir .

CANCER GENETICS AND CYTOGENETICS, 2009, 190 (02) :97-100

[7] Diabetes insipidus revealing acute myelogenous leukaemia with a high platelet count, monosomy 7 and abnormalities of chromosome 3:: a new entity? [J].

Lavabre-Bertrand, T ;

Bourquard, P ;

Chiesa, J ;

Berthéas, MF ;

Lefort, G ;

Taïb, J ;

Lavabre-Bertrand, C ;

Navarro, M ;

Bureau, JP .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2001, 66 (01) :66-69

[8]

Loukidis Konstantinos, 2012, Clin Adv Hematol Oncol, V10, P399

[9]

MASSE SR, 1973, ARCH PATHOL, V96, P141

[10] ACTIVATION OF EVI1 GENE-EXPRESSION IN HUMAN ACUTE MYELOGENOUS LEUKEMIAS BY TRANSLOCATIONS SPANNING 300-400 KILOBASES ON CHROMOSOME BAND-3Q26 [J].

MORISHITA, K ;

PARGANAS, E ;

WILLMAN, CL ;

WHITTAKER, MH ;

DRABKIN, H ;

OVAL, J ;

TAETLE, R ;

VALENTINE, MB ;

IHLE, JN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (09) :3937-3941

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