Mislocalization of cell-cell adhesion complexes in tamoxifen-resistant breast cancer cells with elevated c-Src tyrosine kinase activity

被引：19
作者：
Zhao, Yan [1 ]
Planas-Silva, Maricarmen D. [1 ]
机构：
[1] Penn State Coll Med, Dept Pharmacol, Hershey, PA 17033 USA
来源：
CANCER LETTERS | 2009年 / 275卷 / 02期
关键词：
c-Src tyrosine kinase; Cell-cell adhesion; E-cadherin; beta-Catenin; Tamoxifen; Breast cancer; BETA-CATENIN; E-CADHERIN; ALPHA-CATENIN; INTERCELLULAR-ADHESION; ACTIN CYTOSKELETON; ADHERENS JUNCTIONS; FAMILY KINASES; IN-VITRO; PHOSPHORYLATION; EXPRESSION;
D O I：
10.1016/j.canlet.2008.10.022
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
c-Src activation has been implicated in metastasis of tamoxifen-resistant breast cancer. Here we investigated how c-Src activity affects cell adhesion using a tamoxifen-resistant variant of MCF-7 cells (MTR-3) containing elevated c-Src activity. In MTR-3 cells, adhesion proteins P-catenin and E-cadherin are mislocalized, forming novel structures perpendicular to cell-cell junctions. c-Src is associated with beta-catenin/E-cadherin complexes and beta-catenin tyrosine phosphorylation is enhanced. Blocking c-Src tyrosine kinase activity decreased beta-catenin tyrosine phosphorylation and restored localization of beta-catenin and E-cadherin at cell-cell junctions. These findings suggest that inhibition of c-Src signaling may prevent metastasis of tamoxifen-resistant breast cancer. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：204 / 212
页数：9
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