Human papillomavirus oncoproteins and apoptosis (Review)

被引：47

作者：

Jiang, Peiyue ^{[1
]}

Yue, Ying ^{[1
]}

机构：

[1] Jilin Univ, Hosp 1, Dept Gynecol Oncol, Changchun 130021, Jilin, Peoples R China

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2014年 / 7卷 / 01期

关键词：

human papillomavirus; oncoprotein; incorporation; apoptosis; RISK HUMAN-PAPILLOMAVIRUS; E7; ONCOPROTEIN; TUMOR-SUPPRESSOR; CERVICAL-CANCER; E5; PROTEIN; E6; E2; P53; PATHWAYS; CELLS;

D O I：

10.3892/etm.2013.1374

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The aim of this study was to review the literature and identify the association between human papillomavirus (HPV) oncoproteins and apoptosis. HPV-associated apoptosis may be primarily blocked by a number of oncoproteins, including E5, E6 and E7. E5 protein protects cells from tumor necrosis factor-associated apoptosis; the oncoprotein E6 predominantly inhibits apoptosis through the p53 pathway; and oncoprotein E7 is involved in apoptosis activation and inhibition. In addition, HPV oncoproteins are involved in activating or repressing the transcription of E6/E7. In conclusion, HPV oncoproteins, including E5, E6 and E7 protein, may interfere with apoptosis via certain regulatory principles.

引用

页码：3 / 7

页数：5

共 60 条

[1] HPV typing and its relation with apoptosis in cervical carcinoma from Indian population [J].

Alam, M. Shabbir ;

Ali, Asgar ;

Mehdi, Syed Jafar ;

Alyasiri, Nisreen Sherif ;

Kazim, Zakia ;

Batra, Swaraj ;

Mandal, A. K. ;

Rizvi, M. Moshahid Alam .

TUMOR BIOLOGY, 2012, 33 (01) :17-22

[2] Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer [J].

Arias-Pulido, Hugo ;

Peyton, Cheri L. ;

Joste, Nancy E. ;

Vargas, Hernan ;

Wheeler, Cosette M. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (05) :1755-1762

[3] p53: Guardian of ploidy [J].

Aylon, Yael ;

Oren, Moshe .

MOLECULAR ONCOLOGY, 2011, 5 (04) :315-323

[4] CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2 [J].

Bhattacharjee, Bornali ;

Sengupta, Sharmila .

VIROLOGY, 2006, 354 (02) :280-285

[5] Manipulation of the ubiquitin-proteasome pathway by small DNA tumor viruses [J].

Blanchette, Paola ;

Branton, Philip E. .

VIROLOGY, 2009, 384 (02) :317-323

[6] 1st International Workshop on Papillomavirus E5 Oncogene-A report [J].

Borzacchiello, Giuseppe ;

Roperto, Franco ;

Campo, M. Saveria ;

Venuti, Aldo .

VIROLOGY, 2010, 408 (02) :135-137

[7] CHARACTERIZATION OF THE HUMAN PAPILLOMAVIRUS E2 PROTEIN - EVIDENCE OF TRANSACTIVATION AND TRANSREPRESSION IN CERVICAL KERATINOCYTES [J].

BOUVARD, V ;

STOREY, A ;

PIM, D ;

BANKS, L .

EMBO JOURNAL, 1994, 13 (22) :5451-5459

[8] Human papillomavirus early proteins and apoptosis [J].

Cai, Qiong ;

Lv, Liang ;

Shao, Qian ;

Li, Xiao ;

Dian, Aiping .

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2013, 287 (03) :541-548

[9] The expression of HPV-16 E5 protein in squamous neoplastic changes in the uterine cervix [J].

Chang, JL ;

Tsao, YP ;

Liu, DW ;

Huang, SJ ;

Lee, WH ;

Chen, SL .

JOURNAL OF BIOMEDICAL SCIENCE, 2001, 8 (02) :206-213

[10] TRANSFORMING ACTIVITY OF E5A PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE-6 IN NIH-3T3 AND C127 CELLS [J].

CHEN, SL ;

MOUNTS, P .

JOURNAL OF VIROLOGY, 1990, 64 (07) :3226-3233

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