Exercise protects against spinal cord injury through miR-21-mediated suppression of PDCD4

被引：0
作者：
Li, Meng [1 ]
Jiang, Wan-Ting [2 ]
Li, Jia [1 ]
Ji, Wen-Chen [1 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Orthopaed, Xian 710061, Peoples R China
[2] Fourth Hosp Xian, Dept Ultrasound Diag, Xian 710004, Peoples R China
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2020年 / 12卷 / 09期
关键词：
Exercise; miR-21; PDCD4; spinal cord injury; CYCLING EXERCISE; UP-REGULATION; EXPRESSION; PLASTICITY; MICRORNAS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Spinal cord injury (SCI) can lead to different levels of paraplegia. Studies have shown that exercise exerts wide protective effects against various diseases, and microRNAs (miRNAs) are involved in its beneficial effects. However, the specific role of miRNAs in the protective effects of exercise against SCI remains unclear. Here, we showed that exercise exerted protective effects against SCI as evidenced by increased locomotor activity and spinal cord cell survival in rats with SCI. Exercise upregulated circulating miR-21, detected by miRNA microarray, in rats with SCI. Treating SCI rats with agomiR-21 upregulated circulating miR-21 and exerted protective effects against SCI. Additionally, downregulating miR-21 using antagomir-21 abolished the protective effects of exercise on SCI. Programmed cell death protein 4 (PDCD4) was found to be the target of miR-21. These results suggested that exercise protects against SCI, at least partly, through miR-21-mediated suppression of PDCD4.
引用
收藏
页码：5708 / 5718
页数：11
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