Effects of the NMDA antagonist MK-801 on radial maze performance in histidine-deficient rats

被引：14

作者：

Nishiga, M ^{[1
]}

Sugimoto, Y ^{[1
]}

Taga, C ^{[1
]}

Fujii, Y ^{[1
]}

Kamei, C ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Dept Pharmacol, Okayama 7008530, Japan

来源：

LIFE SCIENCES | 2002年 / 70卷 / 18期

关键词：

histamine; histidine; MK-801; glycine; radial maze; learning and memory;

D O I：

10.1016/S0024-3205(02)01504-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We examined the effects of a histidine-deficient diet on brain histamine contents as well as on learning and memory using the eight-ann radial maze in rats. A significant decrease in histamine content in the hippocampus was observed after long-term feeding of rats with a histidine-deficient diet. At the same time, significant enhancement of the acquisition process in radial maze performance was also observed. Pyrilamine did not show a significant effect on radial maze performance in histidine-deficient rats. On the other hand, pyrilamine caused a significant spatial memory deficit in control rats. Scopolamine was effective in inhibiting spatial memory in both histidine-deficient and control rats. MK-801 caused spatial memory deficits more potently in histidine-deficient rats than in controls. Brain glycine contents showed a significant increase in the hippocampus in histidine-deficient rats. These results indicated that the spatial memory deficits induced by MK-801 in histidine-deficient rats are closely related to increased glycine levels and activation of NMDA receptors. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：2199 / 2208

页数：10

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