TCRαβ+CD3+CD4-CD8- (double negative) T cells in autoimmunity

被引：137

作者：

Brandt, D. ^{[1
]}

Hedrich, C. M. ^{[1
,2
,3
]}

机构：

[1] Tech Univ Dresden, Fac Med Carl Gustav Carus, Childrens Hosp Dresden, Div Pediat Rheumatol & Immunol, Dresden, Germany

[2] Univ Liverpool, Inst Translat Med, Dept Womens & Childrens Hlth, Liverpool, Merseyside, England

[3] Alder Hey Childrens NHS Fdn Trust Hosp, Dept Paediat Rheumatol, Liverpool, Merseyside, England

来源：

AUTOIMMUNITY REVIEWS | 2018年 / 17卷 / 04期

关键词：

Double negative T cells; DN T cells; Effector T cells; SLE; Psoriasis; Inflammation; SYSTEMIC-LUPUS-ERYTHEMATOSUS; LYMPHOPROLIFERATIVE SYNDROME EXPRESS; SJOGRENS-SYNDROME; GENE-EXPRESSION; CD8; EXPRESSION; THYMIC DIFFERENTIATION; REGULATORY CELLS; DNA METHYLATION; CD45; ISOFORM; MURINE B220;

D O I：

10.1016/j.autrev.2018.02.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

TCR alpha beta(+)CD3(+)CD4(-)CD8(-) "double negative" (DN) T cells comprise a small subset of mature peripheral T cells. The origin and function of DN T cells are somewhat unclear and discussed controversially. While DN T cells resemble a rare and heterogeneous T cell subpopulation in healthy individuals, numbers of TCR alpha beta(+) DN T cells are expanded in several inflammatory conditions, where they also exhibit distinct effector phenotypes and infiltrate inflamed tissues. Thus, DN T cells may be involved in systemic inflammation and tissue damage in autoimmune/inflammatory conditions, including SLE, Sjogren's syndrome, and psoriasis. Here, the current understanding of the origin and phenotype of DN T cells, and their role in the instruction of immune responses, autoimmunity and inflammation will be discussed in health and disease. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：422 / 430

页数：9

共 120 条

[51] Hierarchical interactions of control elements determine CD8α gene expression in subsets of thymocytes and peripheral T cells [J].