TCRαβ+CD3+CD4-CD8- (double negative) T cells in autoimmunity

被引：138
作者：
Brandt, D. [1 ]
Hedrich, C. M. [1 ,2 ,3 ]
机构：
[1] Tech Univ Dresden, Fac Med Carl Gustav Carus, Childrens Hosp Dresden, Div Pediat Rheumatol & Immunol, Dresden, Germany
[2] Univ Liverpool, Inst Translat Med, Dept Womens & Childrens Hlth, Liverpool, Merseyside, England
[3] Alder Hey Childrens NHS Fdn Trust Hosp, Dept Paediat Rheumatol, Liverpool, Merseyside, England
来源：
AUTOIMMUNITY REVIEWS | 2018年 / 17卷 / 04期
关键词：
Double negative T cells; DN T cells; Effector T cells; SLE; Psoriasis; Inflammation; SYSTEMIC-LUPUS-ERYTHEMATOSUS; LYMPHOPROLIFERATIVE SYNDROME EXPRESS; SJOGRENS-SYNDROME; GENE-EXPRESSION; CD8; EXPRESSION; THYMIC DIFFERENTIATION; REGULATORY CELLS; DNA METHYLATION; CD45; ISOFORM; MURINE B220;
D O I：
10.1016/j.autrev.2018.02.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
TCR alpha beta(+)CD3(+)CD4(-)CD8(-) "double negative" (DN) T cells comprise a small subset of mature peripheral T cells. The origin and function of DN T cells are somewhat unclear and discussed controversially. While DN T cells resemble a rare and heterogeneous T cell subpopulation in healthy individuals, numbers of TCR alpha beta(+) DN T cells are expanded in several inflammatory conditions, where they also exhibit distinct effector phenotypes and infiltrate inflamed tissues. Thus, DN T cells may be involved in systemic inflammation and tissue damage in autoimmune/inflammatory conditions, including SLE, Sjogren's syndrome, and psoriasis. Here, the current understanding of the origin and phenotype of DN T cells, and their role in the instruction of immune responses, autoimmunity and inflammation will be discussed in health and disease. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：422 / 430
页数：9
相关论文
共 120 条
[1]   Unmasking the pathogenic role of IL-17 axis in primary Sjogren's syndrome: A new era for therapeutic targeting? [J].
Alunno, Alessia ;
Carubbi, Francesco ;
Bartoloni, Elena ;
Bistoni, Onelia ;
Caterbi, Sara ;
Cipriani, Paola ;
Giacomelli, Roberto ;
Gerli, Roberto .
AUTOIMMUNITY REVIEWS, 2014, 13 (12) :1167-1173
[2]   IL-17-producing CD4-CD8- T cells are expanded in the peripheral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary Sjogren's syndrome [J].
Alunno, Alessia ;
Bistoni, Onelia ;
Bartoloni, Elena ;
Caterbi, Sara ;
Bigerna, Barbara ;
Tabarrini, Alessia ;
Mannucci, Roberta ;
Falini, Brunangelo ;
Gerli, Roberto .
ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (02) :286-292
[3]   Lymphostromal interactions in thymic development and function [J].
Anderson, G ;
Jenkinson, EJ .
NATURE REVIEWS IMMUNOLOGY, 2001, 1 (01) :31-40
[4]   Normal mouse kidneys contain activated and CD3+CD4-CD8- double-negative T lymphocytes with a distinct TCR repertoire [J].
Ascon, Dolores B. ;
Ascon, Miguel ;
Satpute, Shailesh ;
Lopez-Briones, Sergio ;
Racusen, Lorraine ;
Colvin, Robert B. ;
Soloski, Mark J. ;
Rabb, Hamid .
JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 84 (06) :1400-1409
[5]   The timing of TCRα expression critically influences T cell development and selection [J].
Baldwin, TA ;
Sandau, MM ;
Jameson, SC ;
Hogquist, KA .
JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (01) :111-121
[6]   Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR [J].
Bilic, I ;
Koesters, C ;
Unger, B ;
Sekimata, M ;
Hertweck, A ;
Maschek, R ;
Wilson, CB ;
Ellmeier, W .
NATURE IMMUNOLOGY, 2006, 7 (04) :392-400
[7]   Human T cell activation induces the expression of a novel CD45 isoform that is analogous to murine B220 and is associated with altered O-glycan synthesis and onset of apoptosis [J].
Bleesing, JJH ;
Morrow, MR ;
Uzel, G ;
Fleisher, TA .
CELLULAR IMMUNOLOGY, 2001, 213 (01) :72-81
[8]   A composite picture of TcRα/β+ CD4-CD8- T cells (α/β-DNTCs) in humans with autoimmune lymphoproliferative syndrome [J].
Bleesing, JJH ;
Brown, MR ;
Novicio, C ;
Guarraia, D ;
Dale, JK ;
Straus, SE ;
Fleisher, TA .
CLINICAL IMMUNOLOGY, 2002, 104 (01) :21-30
[9]   TcR-α/β+ CD4-CD8- T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis [J].
Bleesing, JJH ;
Brown, MR ;
Dale, JK ;
Straus, SE ;
Lenardo, MJ ;
Puck, JM ;
Atkinson, TP ;
Fleisher, TA .
CLINICAL IMMUNOLOGY, 2001, 100 (03) :314-324
[10]   Role of CD8β domains in CD8 coreceptor function:: Importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus [J].
Bosselut, R ;
Kubo, S ;
Guinter, T ;
Kopacz, JL ;
Altman, JD ;
Feigenbaum, L ;
Singer, A .
IMMUNITY, 2000, 12 (04) :409-418
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