Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer's Disease

被引：18

作者：

Xie, Jingdun ^{[1
]}

Wang, Haitao ^{[2
]}

Lin, Ting ^{[3
]}

Bi, Bingtian ^{[4
]}

机构：

[1] Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med,Dept Anesthesiol, Guangzhou 510060, Guangdong, Peoples R China

[2] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China

[3] Guangdong Gen Hosp, Guangdong Acad Med Sci, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Dept Clin Trial Ctr,Collaborat Innovat Ctr Canc M, Guangzhou 510060, Guangdong, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2017年 / 2017卷

关键词：

FLUID SOLUBLE TREM2; MOUSE MODEL; TRANSGENIC MICE; RECEPTOR; 4; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; COMMON VARIANTS; INNATE IMMUNITY; DENTATE GYRUS; A-BETA;

D O I：

10.1155/2017/2986460

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The main hallmarks of Alzheimer's disease (AD) are extracellular deposits of amyloid plaques and intracellular accumulation of hyperphosphorylated neurofibrillary tangles (tau). However, the mechanisms underlying these neuropathological changes remain largely unclear. To date, plenty of studies have shown that microglia-mediated neuroinflammation contributes to the pathogenesis of AD, and the microglia-synapse pathways have been repeatedly identified as the crucial factor in the disease process. In this review, evidences from microglia and synapse studies are presented, and the role of microglia in the pathogenesis of AD, the contributing factors to synapse dysfunction, and the role and mechanisms of microglia-synapse pathways will be discussed.

引用

页数：11

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