On the relevance of hydroxyl radical to purine DNA damage

被引:64
作者
Chatgilialoglu, Chryssostomos [1 ,2 ]
Ferreri, Carla [1 ]
Krokidis, Marios G. [3 ]
Masi, Annalisa [1 ,4 ]
Terzidis, Michael A. [5 ]
机构
[1] CNR, ISOF, Bologna, Italy
[2] Adam Mickiewicz Univ, Ctr Adv Technol, Poznan, Poland
[3] NCSR Demokritos, Inst Nanosci & Nanotechnol, Athens, Greece
[4] CNR, Ist Cristallog, Monterotondo, Italy
[5] Int Hellenic Univ, Dept Nutr Sci & Dietet, Thessaloniki, Greece
关键词
Hydroxyl radical; DNA oxidation; oxidative damage; reactive oxygen species (ROS); cyclopurines;
D O I
10.1080/10715762.2021.1876855
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hydroxyl radical (HO center dot) is the most reactive toward DNA among the reactive oxygen species (ROS) generated in aerobic organisms by cellular metabolisms. HO center dot is generated also by exogenous sources such as ionizing radiations. In this review we focus on the purine DNA damage by HO center dot radicals. In particular, emphasis is given on mechanistic aspects for the various lesion formation and their interconnections. Although the majority of the purine DNA lesions like 8-oxo-purine (8-oxo-Pu) are generated by various ROS (including HO center dot), the formation of 5 ',8-cyclopurine (cPu) lesions in vitro and in vivo relies exclusively on the HO center dot attack. Methodologies generally utilized for the purine lesions quantification in biological samples are reported and critically discussed. Recent results on cPu and 8-oxo-Pu lesions quantification in various types of biological specimens associated with the cellular repair efficiency as well as with distinct pathologies are presented, providing some insights on their biological significance.
引用
收藏
页码:384 / 404
页数:21
相关论文
共 50 条
[41]   Scavenging of hydroxyl radical by catecholamines [J].
Kladna, Aleksandra ;
Berczynski, Pawel ;
Kruk, Irena ;
Michalska, Teresa ;
Aboul-Enein, Hassan Y. .
LUMINESCENCE, 2012, 27 (06) :473-477
[42]   CHEMICAL DETERMINATION OF FREE RADICAL-INDUCED DAMAGE TO DNA [J].
DIZDAROGLU, M .
FREE RADICAL BIOLOGY AND MEDICINE, 1991, 10 (3-4) :225-242
[43]   Free radical-induced damage to DNA: Mechanisms and measurement [J].
Dizdaroglu, M ;
Jaruga, P ;
Birincioglu, M ;
Rodriguez, H .
FREE RADICAL BIOLOGY AND MEDICINE, 2002, 32 (11) :1102-1115
[44]   Serum Hydroxyl Radical Scavenging Capacity as Quantified with Iron-Free Hydroxyl Radical Source [J].
Endo, Nobuyuki ;
Oowada, Shigeru ;
Sueishi, Yoshimi ;
Shimmei, Masashi ;
Makino, Keisuke ;
Fujii, Hirotada ;
Kotake, Yashige .
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 2009, 45 (02) :193-201
[45]   Determination of hydroxyl radical by capillary electrophoresis and studies on hydroxyl radical scavenging activities of Chinese herbs [J].
Yuhua Cao ;
Qingcui Chu ;
Jiannong Ye .
Analytical and Bioanalytical Chemistry, 2003, 376 :691-695
[46]   Determination of hydroxyl radical by capillary electrophoresis and studies on hydroxyl radical scavenging activities of Chinese herbs [J].
Cao, YH ;
Chu, QC ;
Ye, JN .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2003, 376 (05) :691-695
[47]   Herba Ecliptae Protects against Hydroxyl Radical-induced Damages to DNA and Mesenchymal Stem Cells via Antioxidant Mechanism [J].
Han, Lu ;
Sun, Chengjie ;
Lin, Jian ;
Li, Fei ;
Li, Xican ;
Wu, Zisheng ;
Liu, Chengping ;
Bai, Ye ;
Mai, Wenqiong ;
Chen, Dongfeng .
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2014, 61 (10) :1161-1167
[48]   Failure of carboxymethylglucan to inhibit oxidative DNA damage induced by hydroxyl radicals or singlet oxygen [J].
Gábelová, A ;
Plesková, M .
NEOPLASMA, 2000, 47 (06) :354-361
[50]   Protective effects of ethanolic extracts of buckwheat groats on DNA damage caused by hydroxyl radicals [J].
Cao Wei ;
Chen Wei-Jun ;
Suo Zhi-Rong ;
Yao Ya-Ping .
FOOD RESEARCH INTERNATIONAL, 2008, 41 (09) :924-929