Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems

被引：115

作者：

Ohno, Shin-ichiro ^{[1
]}

Drummen, Gregor P. C. ^{[2
]}

Kuroda, Masahiko ^{[1
]}

机构：

[1] Tokyo Med Univ, Dept Mol Pathol, Shinjuku Ku, 6-1-1 Shinjuku, Tokyo 1608402, Japan

[2] Bio & Nano Solut, Bionanosci & Bioimaging Program, Cellular Stress & Ageing Program, D-33647 Bielefeld, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 02期

关键词：

exosome; microvesicle; extracellular vesicle; dexosome; outer membrane vesicle; stem cell; drug delivery system; vaccine; clinical trial; MESENCHYMAL STEM-CELLS; ACTIVATION-RELATED PSEUDOALLERGY; EXOSOME-MEDIATED TRANSFER; ASCITES-DERIVED EXOSOMES; OUTER-MEMBRANE VESICLES; DENDRITIC CELLS; STROMAL CELLS; TUMOR-GROWTH; DELIVERY; MICROVESICLES;

D O I：

10.3390/ijms17020172

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many types of cells release phospholipid membrane vesicles thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents. Extracellular vesicles (EVs) carry various proteins, messenger RNAs (mRNAs), and microRNAs (miRNAs), like a message in a bottle to cells in remote locations. The encapsulated molecules are protected from multiple types of degradative enzymes in body fluids, making EVs ideal for delivering drugs. This review presents an overview of the potential roles of EVs as natural drugs and novel drug-delivery systems.

引用

页数：19

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