Clinical phenotype classification for selective immunoglobulin A deficiency

被引：43

作者：

Yazdani, Reza ^{[1
,2
]}

Latif, AmirHossein ^{[1
]}

Tabassomi, Firouzeh ^{[1
]}

Abolhassani, Hassan ^{[1
,3
]}

Azizi, Gholamreza ^{[1
,4
]}

Rezaei, Nima ^{[1
,5
]}

Aghamohammadi, Asghar ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Res Ctr Immunodeficiencies, Tehran, Iran

[2] Isfahan Univ Med Sci, Sch Med, Dept Immunol, Esfahan, Iran

[3] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Dept Lab Med,Div Clin Immunol, Stockholm, Sweden

[4] Alborz Univ Med Sci, Imam Hassan Mojtaba Hosp, Karaj, Iran

[5] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2015年 / 11卷 / 11期

关键词：

allergic; asymptomatic; autoimmune; classification; minor infectious; selective immunoglobulin A deficiency; severe phenotypes; COMMON VARIABLE IMMUNODEFICIENCY; DEAMIDATED GLIADIN PEPTIDES; IGA DEFICIENCY; CELIAC-DISEASE; BLOOD-DONORS; B-CELLS; ANTIBODIES; SUSCEPTIBILITY; POPULATION; CHILDREN;

D O I：

10.1586/1744666X.2015.1081565

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Selective immunoglobulin A deficiency (SIgAD) is the most common predominantly antibody deficiency, with a wide range of presentations from asymptomatic to severe manifestations. Although many studies have investigated different aspects of SIgAD, no study has yet presented a comprehensive classification of this disease. Based on clinical manifestation of patients and various immune abnormalities associated with SIgAD, this group of patients could be classified into five different phenotypes including asymptomatic, minor infectious, allergic, autoimmune and severe phenotypes. This classification aids physicians in identifying patients and in choosing appropriate management and treatment as well as homogenized groups for molecular and genetic studies.

引用

页码：1245 / 1254

页数：10

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