Enantioselective Aza-Michael/Protonation Reactions in Water

被引：13

作者：

Kitanosono, Taku ^{[1
]}

Sakai, Masaru ^{[1
]}

Zhu, Lei ^{[1
]}

Kobayashi, Shu ^{[1
]}

机构：

[1] Univ Tokyo, Sch Sci, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan

来源：

CHEMISTRY LETTERS | 2019年 / 48卷 / 08期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

Enantioselective protonation; Water; Asymmetric catalysis; CONJUGATE ADDITION; PROTONATION; ANILINE; AMINES;

D O I：

10.1246/cl.190317

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of a chiral copper(II) complex combined with surfactant enabled a tandem nucleophilic addition/protonation sequence of alpha-branched enones in water. Optically active alpha-methyl-beta-amino ketones were obtained with up to 82% ee. The involvement of hydroxy groups of chiral ligand L1 was suggested to be of importance.

引用

收藏

页码：783 / 786

页数：4

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