Allogeneic hematopoietic cell transplantation for mycosis fungoides and Sezary syndrome

被引：81

作者：

Lechowicz, M. J. ^{[1
]}

Lazarus, H. M. ^{[2
]}

Carreras, J. ^{[3
]}

Laport, G. G. ^{[4
]}

Cutler, C. S. ^{[5
]}

Wiernik, P. H. ^{[6
]}

Hale, G. A. ^{[7
]}

Maharaj, D. ^{[8
]}

Gale, R. P. ^{[9
]}

Rowlings, P. A. ^{[10
]}

Freytes, C. O. ^{[11
,12
]}

Miller, A. M. ^{[13
]}

Vose, J. M. ^{[14
]}

Maziarz, R. T. ^{[15
]}

Montoto, S. ^{[16
]}

Maloney, D. G. ^{[17
]}

Hari, P. N. ^{[3
]}

机构：

[1] Emory Univ Hosp, Atlanta, GA 30322 USA

[2] Univ Hosp, Case Med Ctr, Seidman Canc Ctr, Cleveland, OH USA

[3] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA

[4] Stanford Univ, Med Ctr, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA

[5] Dana Farber Canc Inst, Boston, MA 02115 USA

[6] Our Lady Mercy Med Ctr, Bronx, NY USA

[7] Childrens Hosp, Pediatr Hematol Oncol BMT, St Petersburg, FL USA

[8] South Florida Bone Marrow Stem Cell Transplant In, Boynton Beach, FL USA

[9] Univ London Imperial Coll Sci Technol & Med, Dept Med, Div Expt Med, Sect Hematol, London, England

[10] Univ Newcastle, HAPS Pathol North, Calvary Mater Newcastle, Callaghan, NSW 2308, Australia

[11] South Texas Vet Hlth Care Syst, San Antonio, TX USA

[12] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

[13] Baylor Univ, Med Ctr, Dallas, TX USA

[14] Nebraska Med Ctr, Div Hematol Oncol, Omaha, NE USA

[15] Oregon Hlth & Sci Univ, Ctr Hematol Malignancies, Portland, OR 97201 USA

[16] Queen Mary Univ London, Barts Canc Inst, London, England

[17] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

来源：

BONE MARROW TRANSPLANTATION | 2014年 / 49卷 / 11期

关键词：

BONE-MARROW-TRANSPLANTATION; INTERNATIONAL-SOCIETY; LYMPHOMA; ORGANIZATION; BLOOD;

D O I：

10.1038/bmt.2014.161

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We describe outcomes after allogeneic hematopoietic cell transplantation (HCT) for mycosis fungoides and Sezary syndrome (MF/SS). Outcomes of 129 subjects with MF/SS reported to the Center for the International Blood and Marrow Transplant from 2000-2009. Median time from diagnosis to transplant was 30 (4-206) months and most subjects were with multiply relapsed/refractory disease. The majority (64%) received non-myeloablative conditioning (NST) or reduced intensity conditioning (RIC). NST/RIC recipients were older in age compared with myeloablative recipients (median age 51 vs 44 years, P = 0.005) and transplanted in recent years. Non-relapse mortality (NRM) at 1 and 5 years was 19% (95% confidence interval (CI) 12-27%) and 22% (95% CI 15-31%), respectively. Risk of disease progression was 50% (95% CI 41-60%) at 1 year and 61% (95% CI 50-71%) at 5 years. PFS at 1 and 5 years was 31% (95% CI 22-40%) and 17% (95% CI 9-26%), respectively. OS at 1 and 5 years was 54% (95% CI 45-63%) and 32% (95% CI 22-44%), respectively. Allogeneic HCT in MF/SS results in 5-year survival in approximately one-third of patients and of those, half remain disease-free.

引用

页码：1360 / 1365

页数：6

共 15 条

[1] Survival Outcomes and Prognostic Factors in Mycosis Fungoides/Sezary Syndrome: Validation of the Revised International Society for Cutaneous Lymphomas/European Organisation for Research and Treatment of Cancer Staging Proposal [J].

Agar, Nita Sally ;

Wedgeworth, Emma ;

Crichton, Siobhan ;

Mitchell, Tracey J. ;

Cox, Michael ;

Ferreira, Silvia ;

Robson, Alistair ;

Calonje, Eduardo ;

Stefanato, Catherine M. ;

Wain, Elizabeth Mary ;

Wilkins, Bridget ;

Fields, Paul A. ;

Dean, Alan ;

Webb, Katherine ;

Scarisbrick, Julia ;

Morris, Stephen ;

Whittaker, Sean J. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (31) :4730-4739

[2] Defining the Intensity of Conditioning Regimens: Working Definitions [J].

Bacigalupo, Andrea ;

Ballen, Karen ;

Rizzo, Doug ;

Giralt, Sergio ;

Lazarus, Hillard ;

Ho, Vincent ;

Apperley, Jane ;

Slavin, Shimon ;

Pasquini, Marcelo ;

Sandmaier, Brenda M. ;

Barrett, John ;

Blaise, Didier ;

Lowski, Robert ;

Horowitz, Mary .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2009, 15 (12) :1628-1633

[3]

BIGLER RD, 1991, BONE MARROW TRANSPL, V7, P133

[4] Allogeneic stem cell transplantation for advanced cutaneous T-cell lymphomas: a study from the French Society of Bone Marrow Transplantation and French Study Group on Cutaneous Lymphomas [J].

de Masson, Adele ;

Beylot-Barry, Marie ;

Bouaziz, Jean-David ;

de Latour, Regis Peffault ;

Aubin, Francois ;

Garciaz, Sylvain ;

d'Incan, Michel ;

Dereure, Olivier ;

Dalle, Stephane ;

Dompmartin, Anne ;

Suarez, Felipe ;

Battistella, Maxime ;

Vignon-Pennamen, Marie-Dominique ;

Rivet, Jacqueline ;

Adamski, Henri ;

Brice, Pauline ;

Francois, Sylvie ;

Lissandre, S Verine ;

Turlure, Pascal ;

Wierzbicka-Hainaut, Ewa ;

Brissot, Eolia ;

Dulery, Remy ;

Servais, Sophie ;

Ravinet, Aurelie ;

Tabrizi, Reza ;

Ingen-Housz-Oro, Saskia ;

Joly, Pascal ;

Socie, Gerard ;

Bagot, Martine .

HAEMATOLOGICA, 2014, 99 (03) :527-534

[5] Haematopoietic stem cell transplantation for patients with primary cutaneous T-cell lymphoma [J].

Duarte, R. F. ;

Schmitz, N. ;

Servitje, O. ;

Sureda, A. .

BONE MARROW TRANSPLANTATION, 2008, 41 (07) :597-604

[6] Allogeneic Hematopoietic Cell Transplantation for Patients With Mycosis Fungoides and Sezary Syndrome: A Retrospective Analysis of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation [J].

Duarte, Rafael F. ;

Canals, Carmen ;

Onida, Francesco ;

Gabriel, Ian H. ;

Arranz, Reyes ;

Arcese, William ;

Ferrant, Augustin ;

Kobbe, Guido ;

Narni, Franco ;

Deliliers, Giorgio Lambertenghi ;

Olavarria, Eduardo ;

Schmitz, Norbert ;

Sureda, Anna .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (29) :4492-4499

[7] Total Skin Electron Beam and Non-Myeloablative Allogeneic Hematopoietic Stem-Cell Transplantation in Advanced Mycosis Fungoides and Sezary Syndrome [J].

Duvic, Madeleine ;

Donato, Michele ;

Dabaja, Bouthaina ;

Richmond, Heather ;

Singh, Lotika ;

Wei, Wei ;

Acholonu, Sandra ;

Khouri, Issa ;

Champlin, Richard ;

Hosing, Chitra .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (14) :2365-2372

[8] Graft-versus-lymphoma effect in refractory cutaneous T-cell lymphoma after reduced-intensity HLA-matched sibling allogeneic stem cell transplantation [J].

Herbert, KE ;

Spencer, A ;

Grigg, A ;

Ryan, G ;

McCormack, C ;

Prince, HM .

BONE MARROW TRANSPLANTATION, 2004, 34 (06) :521-525

[9] A large single-center experience with allogeneic stem-cell transplantation for peripheral T-cell non-Hodgkin lymphoma and advanced mycosis fungoides/Sezary syndrome [J].

Jacobsen, E. D. ;

Kim, H. T. ;

Ho, V. T. ;

Cutler, C. S. ;

Koreth, J. ;

Fisher, D. C. ;

Armand, P. ;

Alyea, E. P. ;

Freedman, A. S. ;

Soiffer, R. J. ;

Antin, J. H. .

ANNALS OF ONCOLOGY, 2011, 22 (07) :1608-1613

[10] Allogeneic Hematopoietic Cell Transplantation (AHCT) for Primary Cutaneous T Cell Lymphoma (CTCL): a Center for International Blood and Marrow Transplant Research (CIBMTR) Review [J].

Lechowicz, Mary Jo ;

Agovi, Manza ;

Carreras, Jeanette ;

Lazarus, Hillard M. ;

Laport, Ginna G. ;

Montoto, Silvia ;

Maloney, David G. ;

Hari, Parameswaran .

BLOOD, 2010, 116 (21) :165-165

← 1 2 →