Epidemiology, Diagnosis, and Treatment of Hymenoptera Venom Allergy in Mastocytosis Patients

被引：44
作者：
Niedoszytko, Marek [1 ]
Bonadonna, Patrizia [2 ]
Elberink, Joanne N. G. Oude [3 ]
Golden, David B. K. [4 ]
机构：
[1] Med Univ Gdansk, Dept Allergol, PL-80210 Gdansk, Poland
[2] Azienda Osped Univ Integrata Verona, Allergy Unit, I-37126 Verona, Italy
[3] Univ Groningen, Univ Med Ctr Groningen, Dept Allergol, NL-9700 RB Groningen, Netherlands
[4] Johns Hopkins Bayview Med Ctr, Div Allergy Immunol, Baltimore, MD 21224 USA
来源：
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2014年 / 34卷 / 02期
关键词：
Hymenoptera venom allergy; Venom immunotherapy; Immunoglobulin E serology; Mastocytosis; INDOLENT SYSTEMIC MASTOCYTOSIS; BASAL SERUM TRYPTASE; MAST-CELL TRYPTASE; STINGING INSECT HYPERSENSITIVITY; PRACTICE PARAMETER UPDATE; URTICARIA PIGMENTOSA; INDUCED ANAPHYLAXIS; SKIN-LESIONS; BONE-MARROW; IMMUNOTHERAPY;
D O I：
10.1016/j.iac.2014.02.004
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Hymenoptera venom allergy is a typical IgE-mediated reaction caused by sensitization to 1 or more allergens of the venom, and accounts for 1.5% to 34% of all cases of anaphylaxis. Patients suffering from mastocytosis are more susceptible to the anaphylactic reactions to an insect sting. This article aims to answer the most important clinical questions raised by the diagnosis and treatment of insect venom allergy in mastocytosis patients. Total avoidance of Hymenoptera is not feasible, and there is no preventive pharmacologic treatment available, although venom immunotherapy reduces the risk of subsequent systemic reactions.
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页码：365 / +
页数：19
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