Do Endothelial Cells Dream of Eclectic Shape?

被引：26

作者：

Bentley, Katie ^{[1
]}

Philippides, Andrew ^{[2
]}

Regan, Erzsebet Ravasz ^{[1
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Vasc Biol Res Ctr, Sch Med, Boston, MA 02215 USA

[2] Univ Sussex, Dept Informat, Ctr Computat Neurosci & Robot, Brighton BN1 9QJ, E Sussex, England

来源：

DEVELOPMENTAL CELL | 2014年 / 29卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

VE-CADHERIN; IN-VITRO; DEVELOPMENTAL BIOLOGY; SHEET MIGRATION; LUMEN FORMATION; GROWTH-FACTOR; ANGIOGENESIS; BEHAVIOR; MODEL; HETEROGENEITY;

D O I：

10.1016/j.devcel.2014.03.019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endothelial cells (ECs) exhibit dramatic plasticity of form at the single- and collective-cell level during new vessel growth, adult vascular homeostasis, and pathology. Understanding how, when, and why individual ECs coordinate decisions to change shape, in relation to the myriad of dynamic environmental signals, is key to understanding normal and pathological blood vessel behavior. However, this is a complex spatial and temporal problem. In this review we show that the multidisciplinary field of Adaptive Systems offers a refreshing perspective, common biological language, and straightforward toolkit that cell biologists can use to untangle the complexity of dynamic, morphogenetic systems.

引用

页码：146 / 158

页数：13

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