BAF: roles in chromatin, nuclear structure and retrovirus integration

被引：134
作者：
Segura-Totten, M
Wilson, KL
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD 21205 USA
[2] Univ Metropolitana, Dept Sci & Technol, San Juan, PR 00928 USA
来源：
TRENDS IN CELL BIOLOGY | 2004年 / 14卷 / 05期
关键词：
D O I：
10.1016/j.tcb.2004.03.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Barrier-to-autointegration factor (BAF) is an essential protein that is highly conserved in metazoan evolution. BAF binds directly to double-stranded DNA, nuclear LEM-domain proteins, lamin A and transcription activators. BAF is also a host cell component of retroviral preintegration complexes. BAF binds matrix, a retroviral protein, and facilitates efficient retroviral DNA integration in vitro through unknown mechanisms. New findings suggest that BAF has structural roles in nuclear assembly and chromatin organization, represses gene expression and might interlink chromatin structure, nuclear architecture and gene regulation in metazoans.
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收藏
页码：261 / 266
页数：6
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