Three-dimensional conductive polycaprolactone/carbon nanotubes scaffolds for peripheral nerve regeneration

被引：6

作者：

Pi, Wei ^{[1
,2
,3
]}

Zhou, Liping ^{[4
]}

Zhang, Wei ^{[1
,2
,3
]}

Liu, Songyang ^{[1
,2
,3
]}

Li, Ci ^{[1
,2
,3
]}

Zhang, Meng ^{[1
,2
,3
]}

Wen, Yongqiang ^{[4
]}

Zhang, Peixun ^{[1
,2
,3
]}

机构：

[1] Peking Univ, Peking Univ Peoples Hosp, Dept Orthoped & Trauma, Beijing, Peoples R China

[2] Peking Univ, Minist Educ, Key Lab Trauma & Neural Regenerat, Beijing, Peoples R China

[3] Natl Ctr Trauma Med, Beijing, Peoples R China

[4] Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing Key Lab Bioengn & Sensing Technol, Beijing, Peoples R China

来源：

JOURNAL OF MATERIALS SCIENCE | 2022年 / 57卷 / 24期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

CARBON NANOTUBES; ELECTRICAL-STIMULATION; AXON REGENERATION; REPAIR; NANOFIBER; PROMOTES; CELLS;

D O I：

10.1007/s10853-022-07336-z

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Development of tissue-engineered alternatives to nerve autografts remains a serious challenge particularly considering the electroactive properties of native peripheral nerves. In this study, three-dimensional (3D) conductive nerve scaffolds composed of polycaprolactone (PCL) and carbon nanotubes (CNTs) were fabricated using an integration molding method. In vitro, the combination of PCL/CNTs scaffolds with electrical stimulation that mimic the endogenous electric fields could significantly promote Schwann cell proliferation and neurotrophic factor genes expression. In vivo, the effects of PCL/CNTs scaffolds on peripheral nerve regeneration were investigated using a 15-mm rat sciatic nerve defect model. Functional and histological tests indicated that PCL/CNTs scaffolds could effectively promote nerve regeneration and functional recovery. Therefore, PCL/CNTs scaffolds are promising candidates for peripheral nerve restoration. [GRAPHICS] .

引用

页码：11289 / 11299

页数：11

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