The vaccine containing recombinant pertussis toxin induces early and long-lasting protection

被引：17
作者：
Rappuoli, R [1 ]
机构：
[1] Chiron Vaccines, I-53100 Siena, Italy
来源：
BIOLOGICALS | 1999年 / 27卷 / 02期
关键词：
D O I：
10.1006/biol.1999.0189
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Most acellular pertussis vaccines contain a form of pertussis toxin (PT) detoxified by chemical treatment. The Chiron-Vaccines product is unique because it contains a genetically detoxified pertussis toxin. This molecule showed absolute safety, an antigenic profile similar to wild-type PT, and an immunogenicity that is superior to all chemically detoxified PTs. In the efficacy trial, the vaccine containing the genetically detoxified PT demonstrated early and long-lasting protection. (C) 1999 The International Association for Biologicals.
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页码：99 / 102
页数：4
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