Eupatilin inhibits OGD/R-induced neuronal injury in PC12 cells

被引：0

作者：

Xu, Jing ^{[1
]}

Hua, Cong ^{[2
]}

Pan, Xiaoqiang ^{[2
]}

Fu, Xijia ^{[3
]}

Wu, Wei ^{[2
]}

机构：

[1] Jilin Univ, Hosp 1, Dept Outpatient, Changchun 130021, Peoples R China

[2] Jilin Univ, Hosp 1, Dept Neurosurg, Xinmin St 71, Changchun 130021, Jilin, Peoples R China

[3] Jilin Univ, Hosp 1, Dept Neurol, Changchun 130021, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2017年 / 10卷 / 04期

关键词：

Eupatilin; oxygen and glucose deprivation/reperfusion (OGD/R); neuronal apoptosis; N-TERMINAL KINASE; OXYGEN-GLUCOSE DEPRIVATION; ISCHEMIA/REPERFUSION INJURY; CEREBRAL-ISCHEMIA; OXIDATIVE STRESS; EPITHELIAL-CELLS; BRAIN-INJURY; ACTIVATION; APOPTOSIS; DAMAGE;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Eupatilin, a pharmacologically active flavone derived from the Artemisia plant species, has been reported to have anti-oxidant, anti-inflammatory, and anti-tumor and neuroprotective activities. Hence, this study was to investigate the effects of eupatilin on oxygen and glucose deprivation/reperfusion (OGD/R) induced neuronal injury in differentiated PC12 cells. Our results showed that eupatilin pretreatment attenuated OGD/R-induced neuronal injury, with evidence of increased cell viability and decreased LDH leakage. It also inhibited OGD/R-induced intracellular ROS production in PC12 cells. In addition, the down-regulation of Bcl-2, up-regulation of Bax and the consequent activation of caspase-3 induced by OGD/R were reversed by eupatilin. Furthermore, eupatilin pretreatment inhibited OGD/R-induced p-JNK and p-p38 expression in PC12 cells. Taken together, these results suggested that eupatilin inhibits OGD/R-induced neuronal injury in PC12 cells through JNK and p38 signaling pathways.

引用

页码：6728 / 6734

页数：7

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