Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

被引：2015

作者：

Dan, Jennifer M. ^{[1
,2
]}

Mateus, Jose ^{[1
]}

Kato, Yu ^{[1
]}

Hastie, Kathryn M. ^{[1
]}

Yu, Esther Dawen ^{[1
]}

Faliti, Caterina E. ^{[1
]}

Grifoni, Alba ^{[1
]}

Ramirez, Sydney, I ^{[1
,2
]}

Haupt, Sonya ^{[1
]}

Frazier, April ^{[1
]}

Nakao, Catherine ^{[1
]}

Rayaprolu, Vamseedhar ^{[1
]}

Rawlings, Stephen A. ^{[2
]}

Peters, Bjoern ^{[1
,3
]}

Krammer, Florian ^{[4
]}

Simon, Viviana ^{[4
,5
,6
]}

Saphire, Erica Ollmann ^{[1
,2
]}

Smith, Davey M. ^{[2
]}

Weiskopf, Daniela ^{[1
]}

Sette, Alessandro ^{[1
,2
]}

Crotty, Shane ^{[1
,2
]}

机构：

[1] La Jolla Inst Immunol LJI, Ctr Infect Dis & Vaccine Res, La Jolla, CA 92037 USA

[2] Univ Calif San Diego UCSD, Dept Med, Div Infect Dis & Global Publ Hlth, La Jolla, CA 92037 USA

[3] Univ Calif San Diego UCSD, Dept Med, La Jolla, CA 92037 USA

[4] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[5] Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, New York, NY 10029 USA

[6] Icahn Sch Med Mt Sinai, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA

来源：

SCIENCE | 2021年 / 371卷 / 6529期

关键词：

B-CELLS;

D O I：

10.1126/science.abf4063

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Understanding immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics and vaccines and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at a6 months after infection. Immunoglobulin G (IgG) to the spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month after symptom onset. SARS-CoV-2-specific CD4(+) T cells and CD8(+) T cells declined with a half-life of 3 to 5 months. By studying antibody, memory B cell, CD4(+) T cell, and CD8(+) T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.

引用

页码：587 / +

页数：28

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