Magnitude and trend of HIV and Treponema pallidum infections among blood donors in Offinso-North District, Ghana: a nine-year retrospective, cross-sectional study

Introduction: Blood transfusion poses a high public health risk to recipients; hence no effort recommended to eradicate or minimize the danger of transmitting the infections. bReproductive Biology should be underestimated at minimizing the risk of TTIs. This study determined the prevalence and trend of HIV and syphilis infections in voluntary blood donors. Method: A retrospective analysis of secondary data from consecutive prospective voluntary blood donors who accessed Nkenkaasu District Hospital's Blood Bank from January 2010 to December 2018 was conducted. Result: Cumulatively, HIV and Treponema pallidum seropositivity identified in the present study was high (19.1%, [95% C.I (0.026-0.028)]) . The prevalence of HIV and syphilis infections were 10.9% (95% C.I (0.098-0.120)) and 8.9% (95% C.I (0.073-0.92)) respectively. Prospective female blood donors were less likely to test positive for T. pagdum than males (OR 0.511, [0.340 - 0.769], p=0.001), but the infection was similar among different ages. The data showed downward trend for both HIV and T. pallidum sero-positivity, (slope=-2.9467, p <0.0001) and (slope=-0.7117, p<0.0001) respectively. Conclusion: Seroprevalence of HIV and Treponema pallidum were high, and their individual or combined seroposifivity pose a significant threat to the safety of blood. Extensive and continuous screening for high-risk behaviours and infectious markers before blood donation is therefore Unit, Department of Obstetrics and Gynaecology, College of Medicine, Pan African University of Life and Earth Sciences Institute (PAULESI), University of Ibadan, Ibadan, Nigeria.