Relationship between plasma cortisol levels, withdrawal symptoms and craving in abstinent and treated heroin addicts

被引：39
作者：
Nava, Felice
Caldiroli, Emanuela
Premi, Stefania
Lucchini, Alfio
机构：
[1] Hosp Castelfranco Veneto, Drug Abuse Unit, Dept Addict Med, I-31033 Castelfranco Veneto Trev, Italy
[2] Drug Abuse Unit, Dept Addict Med, Varese, Italy
[3] Drug Abuse Unit, Dept Addict Med, Brescia, Italy
[4] Drug Abuse Unit 2, Dept Addict Med, Milan, Italy
来源：
JOURNAL OF ADDICTIVE DISEASES | 2006年 / 25卷 / 02期
关键词：
heroin; cortisol; withdrawal symptoms; craving; methadone; buprenorphine;
D O I：
10.1300/J069v25n02_02
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Twelve-month treatment of heroin addicts with methadone or buprenorphine normalized plasma cortisol levels, and controlled withdrawal symptoms as well as craving. During treatment, the time course of plasma cortisol levels and craving was not strictly correlated: heroin craving was more elevated at 12 than at 3 months. The results suggest a correlation between hypercortisolism, withdrawal symptoms and heroin use and suppose a more complex role for craving and its components in drug-taking behaviour. The main goal of the pharmacological treatment of opioid-dependence should be addressed at the normalization of hypothalamic-pituitary-adrenocortical (HPA) axis more than at the control of craving.
引用
收藏
页码：9 / 16
页数：8
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