Mitochondrial DNA A4336G mutation in Alzheimer's and Parkinson's diseases

被引：16

作者：

García-Lozano, JR

Mir, P

Alberca, R

Aguilera, I

Néciga, EG

Fernández-López, O

Cayuela, A

Núñez-Roldan, A

机构：

[1] Hosp Univ Virgen del Rocio, Serv Inmunol, E-41013 Seville, Spain

[2] Hosp Univ Virgen del Rocio, Neurol Serv, E-41013 Seville, Spain

[3] Hosp Univ Virgen del Rocio, Unidad Apoyo Invest, E-41013 Seville, Spain

[4] Hosp Univ Virgen del Rocio, Serv Andaluz Salud, E-41013 Seville, Spain

来源：

EUROPEAN NEUROLOGY | 2002年 / 48卷 / 01期

关键词：

Alzheimer's disease; Parkinson's disease; mitochondrial mutation; genetics;

D O I：

10.1159/000064955

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives: To determine whether the mitochondrial DNA (mtDNA) A4336G mutation represents a risk factor for Spanish patients with both Alzheimer's disease (AD) and Parkinson's disease (PD). Material and Methods: One hundred and sixty-one AD and 106 PD unrelated patients were included in the study. Seventy-eight age-matched and 144 randomly chosen healthy subjects served as controls. The frequency of the A4336G mutation in these groups was compared using the chi(2) and Fisher's exact tests. p < 0.05 was established as a statistically significant differential value. Results: The mtDNA A4336G mutation was present in 1/161 of AD patients (0.6%), in 3/106 of PD patients (2.8%), in 1/78 of age-matched controls (1.3%) and in 2/144 of the randomly chosen controls (11.4%). These differences were not statistically significant. Conclusion: Our results do not support the hypothesis that this mutation represents a risk factor for either AD or PD patients, at least in the case of this Spanish sample.

引用

页码：34 / 36

页数：3

共 18 条

[1] Mitochondrial DNA polymorphisms in pathologically proven Parkinson's disease [J].