Risk factors for incident diabetes mellitus among HIV-infected patients receiving combination antiretroviral therapy in Taiwan: a case-control study

被引:40
作者
Lo, Y-C [3 ]
Chen, M-Y [1 ,2 ]
Sheng, W-H [1 ,2 ]
Hsieh, S-M [1 ,2 ]
Sun, H-Y [1 ,2 ]
Liu, W-C [1 ,2 ]
Wu, P-Y [1 ,2 ]
Wu, C-H [1 ,2 ]
Hung, C-C [1 ,2 ]
Chang, S-C [1 ,2 ]
机构
[1] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan
[2] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan
[3] Ctr Dis Control, Dept Hlth, Taipei, Taiwan
关键词
antiretroviral therapy; case-control study; diabetes mellitus; HIV infection; IMMUNODEFICIENCY-VIRUS-INFECTION; INSULIN-RESISTANCE; PROTEASE INHIBITORS; LACTIC-ACIDOSIS; PERIPHERAL LIPODYSTROPHY; METABOLIC ABNORMALITIES; CARDIOVASCULAR-DISEASE; COHORT; ADULTS; HYPERLIPIDEMIA;
D O I
10.1111/j.1468-1293.2008.00687.x
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Recent studies suggest that patients with HIV infection are at increased risk for incident diabetes mellitus (DM). We investigated the incidence and risk factors of DM among HIV-infected patients receiving combination antiretroviral therapy (CART) in Taiwan. Incident cases of DM were identified among HIV-infected patients at the National Taiwan University Hospital between 1993 and 2006. A retrospective case-control study was conducted after matching cases with controls for sex, age at HIV diagnosis, year of HIV diagnosis, mode of HIV transmission and baseline CD4 lymphocyte count. A multivariate analysis was performed to identify risk factors for incident DM among HIV-infected patients. In 824 HIV-infected patients eligible for analysis, 50 cases of incident DM were diagnosed, resulting in an incidence of 13.1 cases per 1000 person-years of follow-up. In total, 100 matched controls were identified. Risk factors for incident DM were a family history of DM [odds ratio (OR) 2.656; 95% confidence interval (CI) 1.209-5.834], exposure to zidovudine (OR 3.168; 95% CI 1.159-8.661) and current use of protease inhibitors (OR 2.528; 95% CI 1.186-5.389). Incident DM was associated with a family history of DM, exposure to zidovudine and current use of protease inhibitors in HIV-infected patients receiving CART in Taiwan.
引用
收藏
页码:302 / 309
页数:8
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