Risk Assessment in Adult T Cell Leukemia/Lymphoma Treated with Allogeneic Hematopoietic Stem Cell Transplantation

被引：16

作者：

Yoshimitsu, Makoto ^{[1
]}

Tanosaki, Ryuji ^{[2
]}

Kato, Koji ^{[3
]}

Ishida, Takashi ^{[4
]}

Choi, Ilseung ^{[5
]}

Takatsuka, Yoshifusa ^{[6
]}

Fukuda, Takahiro ^{[7
]}

Eto, Tetsuya ^{[8
]}

Hidaka, Michihiro ^{[9
]}

Uchida, Naoyuki ^{[10
]}

Miyamoto, Toshihiro ^{[3
]}

Nakashima, Yasuhiro ^{[5
]}

Moriuchi, Yukiyoshi ^{[11
]}

Nagafuji, Koji ^{[12
]}

Miyazaki, Yasuhiko ^{[13
]}

Ichinohe, Tatsuo ^{[14
]}

Takanashi, Minoko ^{[15
]}

Atsuta, Yoshiko ^{[16
]}

Utsunomiya, Atae ^{[6
]}

机构：

[1] Kagoshima Univ Hosp, Dept Hematol & Immunol, 8-35-1 Sakuragaoka, Kagoshima 8908520, Japan

[2] Keio Univ Hosp, Dept Transfus Med & Cell Therapy, Tokyo, Japan

[3] Kyushu Univ, Grad Sch Med Sci, Dept Med & Biosyst Sci, Fukuoka, Japan

[4] Nagoya City Univ, Grad Sch Med Sci, Dept Hematol & Oncol, Nagoya, Aichi, Japan

[5] Natl Kyushu Canc Ctr, Dept Hematol, Fukuoka, Japan

[6] Imamura Gen Hosp, Dept Hematol, Kagoshima, Japan

[7] Natl Canc Ctr, Dept Hematopoiet Stem Cell Transplantat, Tokyo, Japan

[8] Hamanomachi Hosp, Dept Hematol, Fukuoka, Japan

[9] Natl Hosp Org Kumamoto Med Ctr, Dept Hematol, Kumamoto, Japan

[10] Federat Natl Publ Serv Personnel Mutual Aid Assoc, Dept Hematol, Tokyo, Japan

[11] Sasebo City Gen Hosp, Dept Hematol, Nagasaki, Japan

[12] Kurume Univ Hosp, Dept Med, Div Hematol & Oncol, Fukuoka, Japan

[13] Oita Prefectural Hosp, Dept Hematol, Oita, Japan

[14] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Hematol & Oncol, Hiroshima, Japan

[15] Japanese Red Cross Soc, Blood Serv Headquarters, Tokyo, Japan

[16] Japanese Data Ctr Hematopoiet Cell Transplantat, Nagoya, Aichi, Japan

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2018年 / 24卷 / 04期

基金：

日本学术振兴会;

关键词：

Allogeneic hematopoietic cell transplantation; Comorbidities; Adult T cell leukemia/lymphoma; Hematologic malignancies; Mortality; ACUTE MYELOID-LEUKEMIA; VERSUS-HOST-DISEASE; COMORBIDITY INDEX; PROGNOSTIC INDEX; REDUCED-INTENSITY; LYMPHOMA; OUTCOMES; MORTALITY; IMPACT; SCT;

D O I：

10.1016/j.bbmt.2017.11.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Disease status at allogeneic hematopoietic cell transplantation (HCT) is an important pretransplant prognostic factor of HCT in adult T cell leukemia/lymphoma (ATL); however, other prognostic factors, including comorbidities, were not predictive in small cohort analyses. Several scoring systems (HCT-specific comorbidity index [HCT-CI]/modified European Group for Blood and Marrow Transplantation risk score [mEBMT]) have been adopted to predict HCT outcomes in other hematologic malignancies. We retrospectively evaluated HCT-CI and mEBMT to predict nonrelapse mortality (NRM) in 824 ATL patients registered in the Japan Society for Hematopoietic Cell Transplantation TRUMP database, from 2008 until 2013. A higher HCT-CI was associated with greater NRM when comparing HCT-CI 0 versus HCT-CI 1 to 3 and HCT-CI 0 versus HCT-CI >= 4. A higher mEBMT score was not associated with higher NRM when comparing mEBMT 0 to 3 with 4 to 6. Because ATL patients are older and consequently at risk of additional complications, we developed an optimized prognostic index for ATL (ATL-HCT-PI) using known risk factors: age, HCT-CI, and donor-recipient sex combination. The ATL-HCT-PI scores effectively predicted the 2-year NRM (22.0%, 27.7%, and 44.4%, respectively). Therefore, the newly developed ATL-HCT-PI, in combination with other risk factors, is more useful for predicting NRM in HCT for ATL patients. (C) 2017 American Society for Blood and Marrow Transplantation.

引用

页码：832 / 839

页数：8

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